Table 2. Effect of CtIP transgenes on... | Rockefeller University Press

Table 2.

Effect of CtIP transgenes on CtIP^−/− lethality

	CtIP^tgCtIP^+/− x CtIP^+/−
Transgenic (CtIP^tg)	CtIP^WTCtIP^−/−	CtIP^T847ACtIP^−/−	CtIP^T847ECtIP^−/−	CtIP^S327ACtIP^−/−
Live-born pups
Observed	7	0	13	14
Expected	12.75	11.75	10.375	13.375
Total mice screened	102	94	83	107

	CtIP^tgCtIP^+/− x CtIP^+/−
Transgenic (CtIP^tg)	CtIP^WTCtIP^−/−	CtIP^T847ACtIP^−/−	CtIP^T847ECtIP^−/−	CtIP^S327ACtIP^−/−
Live-born pups
Observed	7	0	13	14
Expected	12.75	11.75	10.375	13.375
Total mice screened	102	94	83	107

Rescue of CtIP^−/− was assessed in transgenic mice generated by intercrossing CtIP heterozygous mice with one parent carrying a copy of CtIP transgene (CtIP-WT, CtIP-T847A, CtIP-T847E, or CtIP-T327A).

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