Loss of either 53BP1 or KU80 does not rescue CtIP knockout mouse lethality
| CtIP+/-53BP1−/− x CtIP+/−53BP1−/− | CtIP+/−KU80+/− x CtIP+/−Ku80+/− | |||||
| Genotypes | CtIP+/+ 53BP1−/− | CtIP+/− 53BP1−/− | CtIP−/− 53BP−/− | CtIP+/+ KU80−/− | CtIP+/− KU80−/− | CtIP−/− KU80−/− |
| Live-born pups | ||||||
| Observed | 25 | 35 | 0 | 1 | 15 | 0 |
| Expected | 15 | 30 | 15 | 8.0625 | 16.125 | 8.0625 |
| Total mice screened | 60 | 129 | ||||
| CtIP+/-53BP1−/− x CtIP+/−53BP1−/− | CtIP+/−KU80+/− x CtIP+/−Ku80+/− | |||||
| Genotypes | CtIP+/+ 53BP1−/− | CtIP+/− 53BP1−/− | CtIP−/− 53BP−/− | CtIP+/+ KU80−/− | CtIP+/− KU80−/− | CtIP−/− KU80−/− |
| Live-born pups | ||||||
| Observed | 25 | 35 | 0 | 1 | 15 | 0 |
| Expected | 15 | 30 | 15 | 8.0625 | 16.125 | 8.0625 |
| Total mice screened | 60 | 129 | ||||
CtIP+/− 53BP1−/− mice and CtIP+/−Ku80+/− were intercrossed. Genotypes and number of animals generated by the breeding are indicated.