Table 1.

GSEA reveals that signal 3 cytokines during priming promote the expression of cell cycle–associated transcripts

Gene set NES FDR Group No. of enriched genes Genes (ordered by rank) 
Apoptosis 1.12 0.601 DC 9/59 Irf7, Tnfrsf10b, Lta, Jun, Ikbkb, Traf1, Myc, Bcl2, Tnf 
Apoptosis 1.12 0.601 DC+CpG 15/59 Birc5, Gzmb, Tnfsf10, Casp7, Casp4, Prf1, Casp3, Bad, Apaf1, Casp1, Hrk, Fas, Tnfrsf1a, Bnip3l, Dffb 
Cell cycle 2.97 <0.001 DC 0/98 Not applicable 
Cell cycle 2.97 <0.001 DC+CpG 60/98 Hmmr, Bub1, Tpx2, Ckap2l, Pbk, Ccna2, Esco2, Cdc25c, Ckap2, Anln, Cdkn3, Uhrf1, Cccnb2, Cdca8, Ube2c, Asf1b, Melk, Ncaph, Spag5, Top2a, Cdca5, Dhfr, Foxm1, Rad51ap1, Aurka, Bard1, Cdc6, Kif23, Tacc3, Cks1b, Fam83d, Mad2l1, Rrm1, Gmnn, Depdc1b, Exo1, Gins2, Fam64a, Prim1, Wdr51a, Fam72a, Mcm5, Gtse1, Cenpa, Tipin, Mnd1, Cccnf, Mcm8, H2afx, Hells, Rfc4, Fen1, Mcm4, Cdca7, Ube2t, Tyms, Anp32e, Atad2, Mlf1ip 
G1 to S cell cycle reactome 2.27 <0.001 DC 2/59 Atm, E2f5 
G1 to S cell cycle reactome 2.27 <0.001 DC+CpG 21/59 Ccnb1, Mcm7, Cdc45l, Ccne2, Rpa3, Cdkn2c, Orc1l, Prim1, Mcm5, Pole, Mcm3, Ccnd3, E2f2, Cdkn1a, Cdk2, Mcm2, Rb1, Mcm4, Pole2, Wee1, Orc6l 

GSEA gene sets in OT-I CD8 T cells responding to DC alone or DC+CpG immunization at day 7 after immunization.

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