Analysis of an SLE cohort for disease parameters when grouped by the presence (AR IgE+) or absence (AR IgE−) of autoreactive IgE.
| AR IgE− | AR IgE+ | P-value, OR (CI 95%) | |||
| Disease activity n (%) | |||||
| Inactive (SLEDAI = 0) | 52 | (57.8) | 31 | (29.2) | |
| Mild (SLEDAI > 0 and < 4) | 14 | (15.6) | 26 | (24.5) | P = 0.004, 3.12 (1.42-6.84) |
| Active (SLEDAI ≥ 4) | 24 | (26.7) | 49 | (46.2) | P = 0.0002, 3.42 (1.77-6.63) |
| Hypocomplementemia n (%) | |||||
| No | 78 | (86.6) | 68 | (64.1) | |
| Yes | 12 | (13.4) | 38 | (35.8) | P = 0.0003, 3.63 (1.75-7.5) |
| dsDNA IgG positivity n (%) | |||||
| No | 64 | (71.1) | 47 | (44.3) | |
| Yes | 26 | (28.9) | 59 | (55.7) | P = 0.0002, 3.09 (1.70-5.60) |
| Nephritis n (%) | |||||
| Inactive | 50 | (79.4) | 45 | (60.8) | |
| Active | 13 | (20.6) | 29 | (39.2) | P = 0.01, 2.47 (1.14-5.34) |
| AR IgE− | AR IgE+ | P-value, OR (CI 95%) | |||
| Disease activity n (%) | |||||
| Inactive (SLEDAI = 0) | 52 | (57.8) | 31 | (29.2) | |
| Mild (SLEDAI > 0 and < 4) | 14 | (15.6) | 26 | (24.5) | P = 0.004, 3.12 (1.42-6.84) |
| Active (SLEDAI ≥ 4) | 24 | (26.7) | 49 | (46.2) | P = 0.0002, 3.42 (1.77-6.63) |
| Hypocomplementemia n (%) | |||||
| No | 78 | (86.6) | 68 | (64.1) | |
| Yes | 12 | (13.4) | 38 | (35.8) | P = 0.0003, 3.63 (1.75-7.5) |
| dsDNA IgG positivity n (%) | |||||
| No | 64 | (71.1) | 47 | (44.3) | |
| Yes | 26 | (28.9) | 59 | (55.7) | P = 0.0002, 3.09 (1.70-5.60) |
| Nephritis n (%) | |||||
| Inactive | 50 | (79.4) | 45 | (60.8) | |
| Active | 13 | (20.6) | 29 | (39.2) | P = 0.01, 2.47 (1.14-5.34) |
AR IgE, Autoreactive IgE; OR, Odds Ratio; CI, confidence interval.