DNA aberrations in in vitro-expanded hematopoietic progenitor cells.
| Genotype | Break | Gap | Frag | DC | CF | Trans | Radial | 30-39 | 40 | 41+ | Cells | Sex |
| WT | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 10 | 40 | 0 | 50 | F |
| WT | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 7 | 43 | 0 | 50 | M |
| WT | 5 | 3 | 0 | 0 | 1 | 0 | 0 | 12 | 38 | 0 | 50 | F |
| SIRT1Δ/Δ | 3 | 9 | 0 | 0 | 1 | 0 | 0 | 13 | 37 | 0 | 50 | F |
| SIRT1Δ/Δ | 4 | 10 | 0 | 0 | 1 | 0 | 0 | 11 | 39 | 0 | 50 | M |
| SIRT1Δ/Δ | 3 | 5 | 1 | 0 | 3 | 0 | 0 | 7 | 42 | 1 | 50 | F |
| Genotype | Break | Gap | Frag | DC | CF | Trans | Radial | 30-39 | 40 | 41+ | Cells | Sex |
| WT | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 10 | 40 | 0 | 50 | F |
| WT | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 7 | 43 | 0 | 50 | M |
| WT | 5 | 3 | 0 | 0 | 1 | 0 | 0 | 12 | 38 | 0 | 50 | F |
| SIRT1Δ/Δ | 3 | 9 | 0 | 0 | 1 | 0 | 0 | 13 | 37 | 0 | 50 | F |
| SIRT1Δ/Δ | 4 | 10 | 0 | 0 | 1 | 0 | 0 | 11 | 39 | 0 | 50 | M |
| SIRT1Δ/Δ | 3 | 5 | 1 | 0 | 3 | 0 | 0 | 7 | 42 | 1 | 50 | F |
BM from three Sirt1-E4fl/fl, ERT2-Cre mice (SIRT1Δ/Δ) and three Sirt1-E4fl/fl controls (WT) was cultured in the presence of SCF, FLT3L, IL-6, and TPO, and metaphases were harvested after 10 d. Chromosomal DNA aberrations were scored for 50 metaphases per sample. Frag: DNA fragment; DC: dicentric chromosome; CF: centric fusion; Trans: translocation. Number of chromosomes per cell and gender are indicated.