Independent contribution of rs12979860 and TT/-G to HCV clearance
| Response to treatment | Polymorphisms included in the same model | |
| OR (95% CI) | P | |
| All viral genotypes; n = 540 | ||
| Polymorphisms by pairs | ||
| TT/-G | 0.12 (0.03–0.40) | 5.94−4 |
| rs12979860 | 3.41 (1.01–11.4)a | 4.77−2 |
| Viral genotypes 1 and 4, n = 288 | ||
| Polymorphisms by pairs | ||
| TT/-G | 0.16 (0.05–0.55) | 3.60−3 |
| rs12979860 | 1.61 (0.48–5.40)a | 4.44−1 |
| Spontaneous clearanceb | ||
| Polymorphisms by pairs | ||
| TT/-G | 0.42 (0.14–1.30) | 1.31−1 |
| rs12979860 | 0.66 (0.22–1.99) | 4.59−1 |
| Response to treatment | Polymorphisms included in the same model | |
| OR (95% CI) | P | |
| All viral genotypes; n = 540 | ||
| Polymorphisms by pairs | ||
| TT/-G | 0.12 (0.03–0.40) | 5.94−4 |
| rs12979860 | 3.41 (1.01–11.4)a | 4.77−2 |
| Viral genotypes 1 and 4, n = 288 | ||
| Polymorphisms by pairs | ||
| TT/-G | 0.16 (0.05–0.55) | 3.60−3 |
| rs12979860 | 1.61 (0.48–5.40)a | 4.44−1 |
| Spontaneous clearanceb | ||
| Polymorphisms by pairs | ||
| TT/-G | 0.42 (0.14–1.30) | 1.31−1 |
| rs12979860 | 0.66 (0.22–1.99) | 4.59−1 |
Both TT/-G and rs12978960 were introduced in the same logistic regression model. OR, odds ratio; CI, confidence interval. OR represent the additive effect of the mutant allele (-G for TT/-G and T for rs12979860).
When TT/-G was entered into the model, the direction of the association of the T allele of rs12979860 was reversed (OR > 1).
93 individuals with spontaneous HCV clearance were compared to 540 patients with chronic infection