Table 1. GBS clinical isolates... | Rockefeller University Press

Table 1.

GBS clinical isolates associated with preterm labor and mutations in covR/S locus

Isolate number^a	Source	Mutation in covR/S loci^b	Gestational age at birth^c
1	Amniotic fluid	Deletion of adenine residue at position 658 in covS resulting in truncation of CovS at amino acid 220 (CovS 220Stop)	30 wk
1	Chorioamnion	Same as above i.e. CovS 220Stop	30 wk
2	Amniotic fluid	Deletion of 4 nucleotides ‘ATTT’ spanning -110 to -107 upstream to the ATG start codon in the promoter region of covR/S	34 wk
3	Amniotic fluid	Substitution of adenine instead of guanine resulting in amino acid substitution from valine to methionine in CovS (CovS V343M)	26 wk
3	Blood	CovS V343M	26 wk
4	Chorioamnion	CovS V343M	36 wk
5	Chorioamnion	None	36 wk
6	Chorioamnion	None	28 wk

Isolate number^a	Source	Mutation in covR/S loci^b	Gestational age at birth^c
1	Amniotic fluid	Deletion of adenine residue at position 658 in covS resulting in truncation of CovS at amino acid 220 (CovS 220Stop)	30 wk
1	Chorioamnion	Same as above i.e. CovS 220Stop	30 wk
2	Amniotic fluid	Deletion of 4 nucleotides ‘ATTT’ spanning -110 to -107 upstream to the ATG start codon in the promoter region of covR/S	34 wk
3	Amniotic fluid	Substitution of adenine instead of guanine resulting in amino acid substitution from valine to methionine in CovS (CovS V343M)	26 wk
3	Blood	CovS V343M	26 wk
4	Chorioamnion	CovS V343M	36 wk
5	Chorioamnion	None	36 wk
6	Chorioamnion	None	28 wk

In some patients, GBS were isolated from two different locations, and both these isolates had the same mutation in covR/S.

Only nonsynonymous changes are reported.

All women enrolled in the study had preterm labor with intact membranes at ≤34 wk of gestation.