Table I. Defining properties of mouse... | Rockefeller University Press

Table I.

Defining properties of mouse CD8⁺ DCs and human CD141⁺ DCs

Property	Mouse CD8⁺ DCs	Human CD141⁺ DCs	Human equivalent references
Surface markers^a	CD8⁺, CD11b^low, CD24^hi, CD36⁺ CD205⁺ CD172a⁻ Clec9A⁺ DCIR2⁻ Necl2⁺, XCR1⁺	CD1⁻ CD141⁺ Clec9A⁺ Necl2⁺ XCR1⁺	Bachem et al., 2010; Crozat et al., 2010; Jongbloed et al., 2010; Poulin et al., 2010
Developmental transcription factors	Batf3⁺, IRF-8⁺, IRF-4⁻	Batf3⁺, IRF-8⁺, IRF-4⁻	Jongbloed et al., 2010; Poulin et al., 2010
Pathogen sensors^a	TLR1^−/low TLR2⁺ TLR3⁺ TLR4⁺ TLR6^−/low TLR7⁻ TLR9⁺ TLR11/12⁺ RIG⁻	TLR3⁺, TLR7⁻, TLR9⁻	Jongbloed et al., 2010; Poulin et al., 2010
IL-12 production	Yes	Yes	Jongbloed et al., 2010; Poulin et al., 2010
Dead cell uptake	Yes	Yes	Jongbloed et al., 2010; Poulin et al., 2010
Antigen cross-presentation	Yes	Yes	Bachem et al., 2010; Crozat et al., 2010; Jongbloed et al., 2010; Poulin et al., 2010

Property	Mouse CD8⁺ DCs	Human CD141⁺ DCs	Human equivalent references
Surface markers^a	CD8⁺, CD11b^low, CD24^hi, CD36⁺ CD205⁺ CD172a⁻ Clec9A⁺ DCIR2⁻ Necl2⁺, XCR1⁺	CD1⁻ CD141⁺ Clec9A⁺ Necl2⁺ XCR1⁺	Bachem et al., 2010; Crozat et al., 2010; Jongbloed et al., 2010; Poulin et al., 2010
Developmental transcription factors	Batf3⁺, IRF-8⁺, IRF-4⁻	Batf3⁺, IRF-8⁺, IRF-4⁻	Jongbloed et al., 2010; Poulin et al., 2010
Pathogen sensors^a	TLR1^−/low TLR2⁺ TLR3⁺ TLR4⁺ TLR6^−/low TLR7⁻ TLR9⁺ TLR11/12⁺ RIG⁻	TLR3⁺, TLR7⁻, TLR9⁻	Jongbloed et al., 2010; Poulin et al., 2010
IL-12 production	Yes	Yes	Jongbloed et al., 2010; Poulin et al., 2010
Dead cell uptake	Yes	Yes	Jongbloed et al., 2010; Poulin et al., 2010
Antigen cross-presentation	Yes	Yes	Bachem et al., 2010; Crozat et al., 2010; Jongbloed et al., 2010; Poulin et al., 2010

Only markers normally used for CD8⁺ DC or CD141⁺ DC subset discrimination are listed. Clec9A is also known as DNGR1. CD172a is also known asSirpα . CD141 is also known as BDCA 3.