Table 1.

DLK-interacting proteins identified by mass spectrometry

Gene Uniprot Symbol Present in PSD Peptides in DLKlox:Creneg Peptides in DLKlox:Crepos 
DLK MAP3K12 23 
Beta spectrin 2 Spnb2 28 
LZK MAP3K13  13 
Neurofilament light Nefl 13 
Neurofilament medium Nefm 12 
Beta spectrin 3 Spnb3 10 
Internexin Ina 
Matrin 3 Matr3  
Purine rich binding protein element A Pura 
Microtubule associate protein 1A Map1a 
Contactin 1 Cntn1 
Actinin alpha 1 Actn1 
DEAH box polypeptide 9 Dhx9  
Synaptic RAS GTPase activating protein Syngap1 
Microtubule associate protein 4 Map4 
Heterogeneous nuclear ribonucleoprotein a2b1 HNRPa2b1  
BR serine/threonine kinase 1 Brsk1  
PSD-95 DLG4 
Set binding factor 1 sbf1 
Kinesin family member 2A Kif2 
Gene Uniprot Symbol Present in PSD Peptides in DLKlox:Creneg Peptides in DLKlox:Crepos 
DLK MAP3K12 23 
Beta spectrin 2 Spnb2 28 
LZK MAP3K13  13 
Neurofilament light Nefl 13 
Neurofilament medium Nefm 12 
Beta spectrin 3 Spnb3 10 
Internexin Ina 
Matrin 3 Matr3  
Purine rich binding protein element A Pura 
Microtubule associate protein 1A Map1a 
Contactin 1 Cntn1 
Actinin alpha 1 Actn1 
DEAH box polypeptide 9 Dhx9  
Synaptic RAS GTPase activating protein Syngap1 
Microtubule associate protein 4 Map4 
Heterogeneous nuclear ribonucleoprotein a2b1 HNRPa2b1  
BR serine/threonine kinase 1 Brsk1  
PSD-95 DLG4 
Set binding factor 1 sbf1 
Kinesin family member 2A Kif2 

“Present in PSD” denotes peptides identified in PSD fraction after biochemical fractionation. All peptides except DLK and Map4 have been identified in multiple independent studies.

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