IgHMOG-mem/JHT × TCRMOG/JHT mice developed spontaneous EAE
| Mice | Incidence | Onset | Mean maximal clinical score | Mean number of foci (±SEM)a | ||
| Meninges | Parenchyma | Total | ||||
| % | ||||||
| IgHMOG-mem/JHT × TCRMOG/JHT | 55 (21/38) | 60 (±4) | 2.9 (±0.2) | 43 (±25) | 55 (±18) | 98 (±43) |
| IgHB1-8-mem/JHT × TCRMOG/JHT | 0 (0/22) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| TCRMOG/JHT | 0 (0/52) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| IgHMOG-mem/JHT | 0 (0/56) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| IgHMOG-ki | 0 (0/45) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| IgHMOG-ki × TCRMOG | 78 (38/49) | 38 (±2) | 3.8 (±0.1) | 60 (±14) | 51 (±14) | 111 (±24) |
| Mice | Incidence | Onset | Mean maximal clinical score | Mean number of foci (±SEM)a | ||
| Meninges | Parenchyma | Total | ||||
| % | ||||||
| IgHMOG-mem/JHT × TCRMOG/JHT | 55 (21/38) | 60 (±4) | 2.9 (±0.2) | 43 (±25) | 55 (±18) | 98 (±43) |
| IgHB1-8-mem/JHT × TCRMOG/JHT | 0 (0/22) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| TCRMOG/JHT | 0 (0/52) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| IgHMOG-mem/JHT | 0 (0/56) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| IgHMOG-ki | 0 (0/45) | n/a | 0.0 | 0.0 | 0.0 | 0.0 |
| IgHMOG-ki × TCRMOG | 78 (38/49) | 38 (±2) | 3.8 (±0.1) | 60 (±14) | 51 (±14) | 111 (±24) |
n/a, not applicable. Onset indicates mean day of disease onset (paralytic EAE) ± SEM. Clinical score shows mean maximal score of paralytic EAE of diseased mice ± SEM.
The infiltration in the brain and spinal cord is quantified as averaged number of meningeal and parenchymal inflammatory foci (>10 clustered inflammatory cells) per CNS tissue section (five mice/group).