Evaluation of clinical signs and histological EAE in WT, IgHMOG-mem/JHT, and IgHMOG-ki mice
| Ag and mice | Incidence | Onset | Mean maximal clinical score | Mean number of foci (±SEM)a | ||
| Meninges | Parenchyma | Total | ||||
| MOG p35–55 | ||||||
| WT | 15/15 | 11.5 (±0.4) | 3.6 (±0.3) | 238 (±53) | 203 (±39) | 441 (±92) |
| IgHMOG-mem/JHT | 18/18 | 11.4 (±1.1) | 3.7 (±0.3) | 117 (±23) | 117 (±24) | 234 (±47) |
| IgHMOG-ki | 15/15 | 11.6 (±1.2) | 3.8 (±0.2) | 118 (±28) | 138 (±23) | 256 (±51) |
| rmMOG | ||||||
| WT | 15/15 | 11.3 (±0.6) | 3.9 (±0.2) | 160 (±33) | 199 (±41) | 339 (±74) |
| IgHMOG-mem/JHT | 18/18 | 11.4 (±0.2) | 3.9 (±0.2) | 189 (±18) | 199 (±12) | 388 (±30) |
| IgHMOG-ki | 15/15 | 11.8 (±0.8) | 3.8 (±0.3) | 137 (±16) | 145 (±24) | 282 (±30) |
| rhMOG | ||||||
| WT | 18/18 | 11.8 (±0.5) | 3.7 (±0.2) | 154 (±47) | 150 (±10) | 304 (±57) |
| IgHMOG-mem/JHT | 18/18 | 11.8 (±0.7) | 3.0 (±0.2) | 118 (±28) | 139 (±23) | 257 (±51) |
| IgHMOG-ki | 17/18 | 10.4 (±0.4) | 4.2 (±0.3) | 146 (±25) | 139 (±18) | 285 (±43) |
| Ag and mice | Incidence | Onset | Mean maximal clinical score | Mean number of foci (±SEM) | ||
| Meninges | Parenchyma | Total | ||||
| WT | 15/15 | 11.5 (±0.4) | 3.6 (±0.3) | 238 (±53) | 203 (±39) | 441 (±92) |
| IgHMOG-mem/JHT | 18/18 | 11.4 (±1.1) | 3.7 (±0.3) | 117 (±23) | 117 (±24) | 234 (±47) |
| IgHMOG-ki | 15/15 | 11.6 (±1.2) | 3.8 (±0.2) | 118 (±28) | 138 (±23) | 256 (±51) |
| WT | 15/15 | 11.3 (±0.6) | 3.9 (±0.2) | 160 (±33) | 199 (±41) | 339 (±74) |
| IgHMOG-mem/JHT | 18/18 | 11.4 (±0.2) | 3.9 (±0.2) | 189 (±18) | 199 (±12) | 388 (±30) |
| IgHMOG-ki | 15/15 | 11.8 (±0.8) | 3.8 (±0.3) | 137 (±16) | 145 (±24) | 282 (±30) |
| WT | 18/18 | 11.8 (±0.5) | 3.7 (±0.2) | 154 (±47) | 150 (±10) | 304 (±57) |
| IgHMOG-mem/JHT | 18/18 | 11.8 (±0.7) | 3.0 (±0.2) | 118 (±28) | 139 (±23) | 257 (±51) |
| IgHMOG-ki | 17/18 | 10.4 (±0.4) | 4.2 (±0.3) | 146 (±25) | 139 (±18) | 285 (±43) |
Onset indicates mean day of disease onset (paralytic EAE) ± SEM. Clinical score shows mean maximal score of paralytic EAE of diseased mice ± SEM. Composite data from three independent experiments with five to six mice per group are indicated.
The infiltration in the brain and spinal cord is quantified as averaged number of meningeal and parenchymal inflammatory foci (>10 clustered inflammatory cells) per CNS tissue section (five mice/group).
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