Passive transfer of MOG-specific antibodies partially restored EAE susceptibility in B–MHC II−/− mice
| Ag | Incidence | Onset | Mean maximal clinical score | Mean clinical score day 12 | Mean clinical score day 18 | Mean clinical score day 24 | Cumulative score |
| B–MHC II+/+ | |||||||
| rhMOG | 6/6 | 15.0 (±1.2) | 2.5 (±0.4) | 1.3 (±0.5) | 2.6 (±0.3) | 2.9 (±0.2) | 150.0 |
| B–MHC II−/− | |||||||
| rhMOG | 0/4 | - | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 |
| +anti-MOG mAb | 4/4 | 3.0 (±0.0) p.i. | 1.0 (±0.1) | 0.0 (±0.0) | 0.9 (±0.1) | 0.9 (±0.1) | 32.0 |
| +anti-OVA mAb | 0/4 | - | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 |
| Ag | Incidence | Onset | Mean maximal clinical score | Mean clinical score day 12 | Mean clinical score day 18 | Mean clinical score day 24 | Cumulative score |
| rhMOG | 6/6 | 15.0 (±1.2) | 2.5 (±0.4) | 1.3 (±0.5) | 2.6 (±0.3) | 2.9 (±0.2) | 150.0 |
| rhMOG | 0/4 | - | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 |
| +anti-MOG mAb | 4/4 | 3.0 (±0.0) p.i. | 1.0 (±0.1) | 0.0 (±0.0) | 0.9 (±0.1) | 0.9 (±0.1) | 32.0 |
| +anti-OVA mAb | 0/4 | - | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 (±0.0) | 0.0 |
p.i., post injection. Onset indicates mean day of disease onset (paralytic EAE) ± SEM. Clinical score shows mean maximal score of paralytic EAE of diseased mice ± SEM. Mean clinical score shows mean score of paralytic EAE of disease mice ± SEM. Cumulative score shows sum of the daily scores of all animals from day 0 until the end of the experiment.
As a benefit of your subscription, you can share temporary access to restricted articles.
Each link will stop working after 30 days or 10 uses. You may create up to 10 links in a 30 day period.
Please sign in to your personal account to gift article access.
As a benefit of your subscription, you can share temporary access to restricted articles.
Each link will stop working after 30 days or 10 uses. You may create up to 10 links in a 30 day period.
Gift articles remaining: --
Each link will stop working after 30 days or 10 uses. You may create up to 10 links in a 30 day period.
Gift articles remaining: --
As a benefit of your subscription, you can share temporary access to restricted articles.
Each link will stop working after 30 days or 10 uses.
You have reached the limit of 10 links within a 30 day period.
Sharing content requires targeting cookies to be enabled. Please update your cookie preferences to use this feature.