Table 1. Effect of bNAbs on cell-free... | Rockefeller University Press

Table 1.

Effect of bNAbs on cell-free and cell to cell HIV-1 transmission

bNAbs	IC50
	NL4.3		NLAD8
	Cell free	Cell associated	Cell free	Cell associated
NIH45-46	0.06	1.2	0.2	2.5
3BNC60	0.05	0.9	0.1	2.3
VRC01	0.2	7.2^a	0.3	12.1^a
1NC9	0.2	4.5^a	0.7	12.3^a
12A12	9.4^a	X	2.6	X
8ANC195	4.0^a	X	5.7^a	X
10-1074	X	X	0.1	1.6
PGT121	X	X	0.1	1.3
10-1074GM	X	X	0.3	6.2
10-996	X	X	0.1	1.7
10-1369	X	X	0.4	10^a
PG16	0.7^a	>15	0.05	0.5^a
3BC176	0.7^a	X	>15	X
10E8	0.1	6.7^a	1.1	>15
4E10	4.3^a	X	>15	>15

bNAbs	IC50
	NL4.3		NLAD8
	Cell free	Cell associated	Cell free	Cell associated
NIH45-46	0.06	1.2	0.2	2.5
3BNC60	0.05	0.9	0.1	2.3
VRC01	0.2	7.2^a	0.3	12.1^a
1NC9	0.2	4.5^a	0.7	12.3^a
12A12	9.4^a	X	2.6	X
8ANC195	4.0^a	X	5.7^a	X
10-1074	X	X	0.1	1.6
PGT121	X	X	0.1	1.3
10-1074GM	X	X	0.3	6.2
10-996	X	X	0.1	1.7
10-1369	X	X	0.4	10^a
PG16	0.7^a	>15	0.05	0.5^a
3BC176	0.7^a	X	>15	X
10E8	0.1	6.7^a	1.1	>15
4E10	4.3^a	X	>15	>15

The indicated antibodies were tested against cell-free and cell-associated HIV-1 infection as indicated in Fig. 1. Median inhibitory concentrations (IC50) were calculated from at least four independent experiments. The corresponding inhibition curves are displayed Fig. S1. Bold indicates IC50 < 0.5 µg/ml; italics indicate IC50 = 0.5–2 µg/ml; single underline indicates IC50 = 2–10 µg/ml; bold and underline indicate IC50 = 10–15 µg/ml. X, no neutralization (<25% inhibition at 15 µg/ml).

Partial neutralization (<90% inhibition at 15 µg/ml).

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