Table 1. Frequencies of leukocytes in... | Rockefeller University Press

Table 1.

Frequencies of leukocytes in huTLR8Tg chimeras

	Spleen		Blood
	WT	huTLR8Tg	WT	huTLR8Tg
Total spleen cell number	6 × 10⁷ ± 0.2	4 × 10⁷ ± 0.8^a
	%	%	%	%
CD3⁺CD4⁺ T cells	23 ± 0.7	19 ± 1.4	17 ± 1.2	9 ± 1.5^b
Naive (CD62L^hi CD44^low)	72 ± 0.5	55 ± 4.6^c	72 ± 3.5	53 ± 8.3^a
Effector (CD62L^hi CD44^hi)	5.2 ± 0.4	6 ± 0.77	2 ± 0.5	3 ± 0.7
Effector memory (CD62L^lowCD44^hi)	18 ± 0.7	35 ± 5.5^c	18 ± 3.6	39 ± 8^a
CD3⁺CD8⁺ T cells	12 ± 0.5	10 ± 0.7	9.3 ± 1.7	6 ± 1.1
Naive (CD62L^hi CD44^low)	74 ±1.1	58 ± 4.8	74 ± 2.7	46 ± 4^b
Effector (CD62L^hi CD44^hi)	16 ± 0.7	15 ± 2.2	11 ± 1.6	23 ± 3.3^b
Effector memory (CD62L^lowCD44^hi)	7 ± 0.4	23 ± 6^c	11 ± 3.3	24 ± 3.6^a
T reg (CD4⁺ CD8⁺ FOXP3⁺)	1.5 ± 0.3	2 ± 0.4	2 ± 0.3	2 ± 0.4
CD19⁺ B cells	49 ± 1.7	47 ± 3.2	48 ± 4	38 ± 4^a
Monocytes (CD11b⁺Ly6G⁻F4/80⁺)	2 ± 0.2	3 ± 0.3	5 ± 0.6	11 ± 1.4^b
Neutrophils (CD11b⁺Ly6G⁺F4/80⁻)	1 ± 0.14	3 ± 0.4^c	6 ± 1	20 ± 6^c
CD11c⁺ DC	4 ± 0.3	3 ± 0.4	3 ± 0.5	4 ± 0.5

	Spleen		Blood
	WT	huTLR8Tg	WT	huTLR8Tg
Total spleen cell number	6 × 10⁷ ± 0.2	4 × 10⁷ ± 0.8^a
	%	%	%	%
CD3⁺CD4⁺ T cells	23 ± 0.7	19 ± 1.4	17 ± 1.2	9 ± 1.5^b
Naive (CD62L^hi CD44^low)	72 ± 0.5	55 ± 4.6^c	72 ± 3.5	53 ± 8.3^a
Effector (CD62L^hi CD44^hi)	5.2 ± 0.4	6 ± 0.77	2 ± 0.5	3 ± 0.7
Effector memory (CD62L^lowCD44^hi)	18 ± 0.7	35 ± 5.5^c	18 ± 3.6	39 ± 8^a
CD3⁺CD8⁺ T cells	12 ± 0.5	10 ± 0.7	9.3 ± 1.7	6 ± 1.1
Naive (CD62L^hi CD44^low)	74 ±1.1	58 ± 4.8	74 ± 2.7	46 ± 4^b
Effector (CD62L^hi CD44^hi)	16 ± 0.7	15 ± 2.2	11 ± 1.6	23 ± 3.3^b
Effector memory (CD62L^lowCD44^hi)	7 ± 0.4	23 ± 6^c	11 ± 3.3	24 ± 3.6^a
T reg (CD4⁺ CD8⁺ FOXP3⁺)	1.5 ± 0.3	2 ± 0.4	2 ± 0.3	2 ± 0.4
CD19⁺ B cells	49 ± 1.7	47 ± 3.2	48 ± 4	38 ± 4^a
Monocytes (CD11b⁺Ly6G⁻F4/80⁺)	2 ± 0.2	3 ± 0.3	5 ± 0.6	11 ± 1.4^b
Neutrophils (CD11b⁺Ly6G⁺F4/80⁻)	1 ± 0.14	3 ± 0.4^c	6 ± 1	20 ± 6^c
CD11c⁺ DC	4 ± 0.3	3 ± 0.4	3 ± 0.5	4 ± 0.5

Data are from TLR8 Tg clone 12 sacrificed when moribund (50–120 d old) and matching C57BL/6 WT mice; n = 17/per group (mean ± SEM). Main cell populations are represented as percentage of total live spleen or blood cells. Subpopulations are in bold.

P ≤ 0.05.

P ≤ 0.01.

P ≤ 0.001.

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