Table 1. Characteristics of CD27 − and... | Rockefeller University Press

Table 1.

Characteristics of CD27⁻ and CD27⁺ B cells in STAT3-deficient individuals

Parameter	CD27⁻ B cells		CD27⁺ B cells
	Normal	STAT3_MUT	Normal	STAT3_MUT
% Cells	75.2 ± 2.7	94.9 ± 0.77	24.8 ± 2.7	5.1 ± 0.77
% IgM⁺	87.0 ± 2.2	90.0 ± 2.0	47 ± 3.8	48 ± 3.1
% IgD⁺	88.0 ± 1.9	93.0 ± 1.8	41 ± 2.2	45 ± 2.0
% IgG⁺	3.2 ± 0.45	1.6 ± 0.6^a	25 ± 2.1	32 ± 2.8^a
% IgG1⁺ (% total IgG⁺ cells)	2.3 ± 1.0 (62.1)	0.63 ± 0.24 (40.1)	11 ± 1.7 (51.4)	22 ± 2.8 (72.7)^b
% IgG2⁺ (% total IgG⁺ cells)	0.72 ± 0.14 (19.4)	0.54 ± 0.1 (34.4)	6.7 ± 2.1 (31.3)	3.9 ± 0.9 (12.9)
% IgG3⁺ (% total IgG⁺ cells)	0.62 ± 0.15 (16.7)	0.36 ± 0.12 (22.9)	3.6 ± 0.9 (16.8)	4.1 ± 1.1 (13.5)
% IgG4⁺ (% total IgG⁺ cells)	0.065 ± 0.02 (1.8)	0.04 ± 0.014 (2.5)	0.11 ± 0.04 (0.5)	0.27 ± 0.08 (0.9)
% IgA⁺	1.2 ± 0.2	0.64 ± 0.15^a	17 ± 1.2	8.6 ± 1.1^c
% CD23⁺	62.0 ± 3.9	86.0 ± 3.7^c	18 ± 3.9	46 ± 4.7^c

Parameter	CD27⁻ B cells		CD27⁺ B cells
	Normal	STAT3_MUT	Normal	STAT3_MUT
% Cells	75.2 ± 2.7	94.9 ± 0.77	24.8 ± 2.7	5.1 ± 0.77
% IgM⁺	87.0 ± 2.2	90.0 ± 2.0	47 ± 3.8	48 ± 3.1
% IgD⁺	88.0 ± 1.9	93.0 ± 1.8	41 ± 2.2	45 ± 2.0
% IgG⁺	3.2 ± 0.45	1.6 ± 0.6^a	25 ± 2.1	32 ± 2.8^a
% IgG1⁺ (% total IgG⁺ cells)	2.3 ± 1.0 (62.1)	0.63 ± 0.24 (40.1)	11 ± 1.7 (51.4)	22 ± 2.8 (72.7)^b
% IgG2⁺ (% total IgG⁺ cells)	0.72 ± 0.14 (19.4)	0.54 ± 0.1 (34.4)	6.7 ± 2.1 (31.3)	3.9 ± 0.9 (12.9)
% IgG3⁺ (% total IgG⁺ cells)	0.62 ± 0.15 (16.7)	0.36 ± 0.12 (22.9)	3.6 ± 0.9 (16.8)	4.1 ± 1.1 (13.5)
% IgG4⁺ (% total IgG⁺ cells)	0.065 ± 0.02 (1.8)	0.04 ± 0.014 (2.5)	0.11 ± 0.04 (0.5)	0.27 ± 0.08 (0.9)
% IgA⁺	1.2 ± 0.2	0.64 ± 0.15^a	17 ± 1.2	8.6 ± 1.1^c
% CD23⁺	62.0 ± 3.9	86.0 ± 3.7^c	18 ± 3.9	46 ± 4.7^c

Values represent percentage (or absolute number for CD4⁺CXCR5⁺ T cells) of cells expressing the indicated surface molecule; each value represents the mean ± SEM; normal donors: n = 8–24; STAT3 patients: n = 9–27. P-values were determined by Student’s t test, comparing normal with STAT3_MUT B cells.

P < 0.05.

P < 0.01.

P < 0.001.

View Large

This Feature Is Available To Subscribers Only