Table 1.

Common genes responsive to TGF-β in MeT-5A and Y-MESO-27 cells

Symbol Description 
MeT-5A and Y-MESO-27 common genes up (>1.5fold) 
CSF1R colony-stimulating factor 1 receptor 
SNAI1 snail homologue 1 
LOXlysyl oxidase 
RASGRP1 RAS guanyl-releasing protein 1 
MMP2matrix metallopeptidase 2 
ITGA11integrin, alpha 11 
SERPINE1 plasminogen activator inhibitor type 1 
BMP6 bone morphogenetic protein 6 
GDF6 growth differentiation factor 6 
COL1A1Prepro-alpha1(I) collagen 
EDN1 endothelin 1 
COL1A2collagen, type I, alpha 2 
MFAP4 microfibrillar-associated protein 4 
SERPINE2 plasminogen activator inhibitor type 1, member 2 
COL20A1collagen, type XX, alpha 1 
COL5A1collagen, type V, alpha 1 
ITGB3integrin, beta 3 
LTBP2 latent transforming growth factor beta binding protein 2 
SMAD7 SMAD family member 7 
COL7A1collagen, type VII, alpha 1 
SKIL SKI-like oncogene 
COL4A1collagen, type IV, alpha 1 
TGFB1 transforming growth factor, beta 1 
ITGAVintegrin, alpha V (vitronectin receptor) 
IGFBP3 insulin-like growth factor binding protein 3 
COL4A4collagen, type IV, alpha 4 
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 
GADD45B growth arrest and DNA-damage-inducible, beta 
ADAM12 ADAM metallopeptidase domain 12 
BMPR2 bone morphogenetic protein receptor, type II 
ITGA1integrin, alpha 1 
COL16A1collagen, type XVI, alpha 1 
MDAC1 MDAC1 
TGFB2 transforming growth factor, beta 2 
EGR2 early growth response 2 
CTGFconnective tissue growth factor 
ID3 inhibitor of DNA binding 3 
FN1fibronectin 
MeT-5A and Y-MESO-27 common genes down (<0.67-fold) 
IL6R interleukin 6 receptor 
VCAM1 vascular cell adhesion molecule 1 
CASP1 caspase 1, apoptosis-related cysteine peptidase 
IL12A interleukin 12, alpha 
IL1A interleukin 1, alpha 
IL7 interleukin 7 
FAS TNF receptor superfamily, member 6 
MMP26matrix metallopeptidase 26 
FGF23 fibroblast growth factor 23 
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 
NEDD4L neural precursor cell expressed, developmentally down regulated 4-like 
COL24A1collagen, type XXIV, alpha 1 
TGFA transforming growth factor, alpha 
CAMK2D calcium/calmodulin-dependent protein kinase II delta 
TLR3 toll-like receptor 3 
BCL2 B-cell CLL/lymphoma 2 
Symbol Description 
MeT-5A and Y-MESO-27 common genes up (>1.5fold) 
CSF1R colony-stimulating factor 1 receptor 
SNAI1 snail homologue 1 
LOXlysyl oxidase 
RASGRP1 RAS guanyl-releasing protein 1 
MMP2matrix metallopeptidase 2 
ITGA11integrin, alpha 11 
SERPINE1 plasminogen activator inhibitor type 1 
BMP6 bone morphogenetic protein 6 
GDF6 growth differentiation factor 6 
COL1A1Prepro-alpha1(I) collagen 
EDN1 endothelin 1 
COL1A2collagen, type I, alpha 2 
MFAP4 microfibrillar-associated protein 4 
SERPINE2 plasminogen activator inhibitor type 1, member 2 
COL20A1collagen, type XX, alpha 1 
COL5A1collagen, type V, alpha 1 
ITGB3integrin, beta 3 
LTBP2 latent transforming growth factor beta binding protein 2 
SMAD7 SMAD family member 7 
COL7A1collagen, type VII, alpha 1 
SKIL SKI-like oncogene 
COL4A1collagen, type IV, alpha 1 
TGFB1 transforming growth factor, beta 1 
ITGAVintegrin, alpha V (vitronectin receptor) 
IGFBP3 insulin-like growth factor binding protein 3 
COL4A4collagen, type IV, alpha 4 
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 
GADD45B growth arrest and DNA-damage-inducible, beta 
ADAM12 ADAM metallopeptidase domain 12 
BMPR2 bone morphogenetic protein receptor, type II 
ITGA1integrin, alpha 1 
COL16A1collagen, type XVI, alpha 1 
MDAC1 MDAC1 
TGFB2 transforming growth factor, beta 2 
EGR2 early growth response 2 
CTGFconnective tissue growth factor 
ID3 inhibitor of DNA binding 3 
FN1fibronectin 
MeT-5A and Y-MESO-27 common genes down (<0.67-fold) 
IL6R interleukin 6 receptor 
VCAM1 vascular cell adhesion molecule 1 
CASP1 caspase 1, apoptosis-related cysteine peptidase 
IL12A interleukin 12, alpha 
IL1A interleukin 1, alpha 
IL7 interleukin 7 
FAS TNF receptor superfamily, member 6 
MMP26matrix metallopeptidase 26 
FGF23 fibroblast growth factor 23 
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 
NEDD4L neural precursor cell expressed, developmentally down regulated 4-like 
COL24A1collagen, type XXIV, alpha 1 
TGFA transforming growth factor, alpha 
CAMK2D calcium/calmodulin-dependent protein kinase II delta 
TLR3 toll-like receptor 3 
BCL2 B-cell CLL/lymphoma 2 

MeT-5A and Y-MESO-27 cells were treated with TGF-β for 24 h. Total RNA was extracted and subjected to microarray analysis. The genes encoding ECM-related protein are indicated by an asterisk.

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