Table 1. Observed and expected tandem... | Rockefeller University Press

Table 1.

Observed and expected tandem mutations in pol η-deficient cells from spleen and Peyer’s patches

	Polζ^+/+ Polη^−/−				Polζ^+/− Polη^−/−
Mutations per clone	No. of clones	No. of mutations	Tandems observed	Tandems expected^{^a}	No. of clones	No. of mutations	Tandems observed	Tandems expected^{^a}
1	157	157	0	0.00	140	140	0	0.00
2	76	152	3	0.31	77	154	1	0.30
3	34	102	5	0.41	33	99	0	0.40
4	19	76	3	0.46	13	52	4	0.32
5	19	95	5	0.77	11	55	0	0.45
6	9	54	3	0.55	4	24	0	0.24
7	9	63	1	0.77	4	28	2	0.34
8	11	88	4	1.25	4	32	1	0.46
9	5	45	0	0.73	1	9	0	0.15
10	3	30	1	0.55	3	30	1	0.55
11	3	33	1	0.67	0	0	0	0.00
12	2	24	0	0.54	0	0	0	0.00
13	3	39	3	0.95	0	0	0	0.00
14	3	42	0	1.11	1	14	0	0.37
15	4	60	4	1.71	0	0	0	0.00
Total:	357	1,060	33	10.78	291	637	9	3.58

	Polζ^+/+ Polη^−/−				Polζ^+/− Polη^−/−
Mutations per clone	No. of clones	No. of mutations	Tandems observed	Tandems expected^{^a}	No. of clones	No. of mutations	Tandems observed	Tandems expected^{^a}
1	157	157	0	0.00	140	140	0	0.00
2	76	152	3	0.31	77	154	1	0.30
3	34	102	5	0.41	33	99	0	0.40
4	19	76	3	0.46	13	52	4	0.32
5	19	95	5	0.77	11	55	0	0.45
6	9	54	3	0.55	4	24	0	0.24
7	9	63	1	0.77	4	28	2	0.34
8	11	88	4	1.25	4	32	1	0.46
9	5	45	0	0.73	1	9	0	0.15
10	3	30	1	0.55	3	30	1	0.55
11	3	33	1	0.67	0	0	0	0.00
12	2	24	0	0.54	0	0	0	0.00
13	3	39	3	0.95	0	0	0	0.00
14	3	42	0	1.11	1	14	0	0.37
15	4	60	4	1.71	0	0	0	0.00
Total:	357	1,060	33	10.78	291	637	9	3.58

Expected tandems were calculated by the formula n(n − 1)/k in a sequence of k nucleotides long containing n mutations (Winter et al., 1998).