Histopathological features
| ID | Duration | Insulin+ islets | CD8+ cells/islet (islets counted) | Islet HLA class I (pattern) | Tetramer reactivitya (pattern) |
| % | |||||
| Recent onset cases | |||||
| Patient A | <1 wk | Isolated cells only | 8.8 (160) | Positive | Insulin, IGRP (monospecific) |
| Patient B | 1 wk | None | 8.4 (125) | Positive | Insulin, IGRP (monospecific) |
| Patient C | 10 wk | Partial loss | <1 (128) | Positive | HLA-mismatched control (no staining) |
| Patient D | 6 mo | 25 | 3.5 (116) | Positive | Insulin |
| Patient E | 9 mo | 50 | 4.1 (150) | Positive | Insulin |
| Longstanding cases | |||||
| Patient 1 | 1 yr | <50 | 3.2 (140) | Positive | IGRP |
| Patient 2 | 1 yr | 10 | 4.3 (40) | Positive | IGRP, IA-2, insulin (mono-/multispecific) |
| Patient 3 | 3 yr | 15 | 1.5 (70) | Positive | No staining |
| Patient 4 | 3 yr | 39 | 6.5 (20) | Positive | IGRP, GAD65, ppIAPP, insulin (multispecific) |
| Patient 5 | 7 yr | 70 | 9.4 (30) | Positive (tail region only) | IGRP, GAD65, PPI, insulin, IA-2 (mono-/multispecific) |
| Patient 6 | 8 yr | 70 | 3.5 (20) | Positive (lobular) | No staining |
| ID | Duration | Insulin+ islets | CD8+ cells/islet (islets counted) | Islet HLA class I (pattern) | Tetramer reactivitya (pattern) |
| % | |||||
| Recent onset cases | |||||
| Patient A | <1 wk | Isolated cells only | 8.8 (160) | Positive | Insulin, IGRP (monospecific) |
| Patient B | 1 wk | None | 8.4 (125) | Positive | Insulin, IGRP (monospecific) |
| Patient C | 10 wk | Partial loss | <1 (128) | Positive | HLA-mismatched control (no staining) |
| Patient D | 6 mo | 25 | 3.5 (116) | Positive | Insulin |
| Patient E | 9 mo | 50 | 4.1 (150) | Positive | Insulin |
| Longstanding cases | |||||
| Patient 1 | 1 yr | <50 | 3.2 (140) | Positive | IGRP |
| Patient 2 | 1 yr | 10 | 4.3 (40) | Positive | IGRP, IA-2, insulin (mono-/multispecific) |
| Patient 3 | 3 yr | 15 | 1.5 (70) | Positive | No staining |
| Patient 4 | 3 yr | 39 | 6.5 (20) | Positive | IGRP, GAD65, ppIAPP, insulin (multispecific) |
| Patient 5 | 7 yr | 70 | 9.4 (30) | Positive (tail region only) | IGRP, GAD65, PPI, insulin, IA-2 (mono-/multispecific) |
| Patient 6 | 8 yr | 70 | 3.5 (20) | Positive (lobular) | No staining |
patients A, B, C, D, E, 1, and 3 were stained for reactivity against IGRP, insulin, and PPI in Siena. Patients 2, 4, 5, and 6 were stained for reactivity against IGRP, insulin, PPI, IA-2, GAD65, and ppIAPP in La Jolla.