Functional outcome after stroke according to Tp53 Arg72Pro genotypes
| Genotype | Ischemic stroke | ICH | ||||||
| Cohort 1 (P < 0.0001) | Cohort 2 (P = 0.020) | Cohort 1 (P < 0.0001) | Cohort 2 (P = 0.004) | |||||
| Good prognosis | Poor prognosis | Good prognosis | Poor prognosis | Good prognosis | Poor prognosis | Good prognosis | Poor prognosis | |
| Arg/Arg | 104 (44.3) | 131 (55.7) | 35 (57.4) | 26 (42.6) | 13 (19.4) | 54 (80.6) | 8 (26.7) | 22 (73.3) |
| Arg/Pro | 117 (79.6) | 30 (20.4) | 27 (77.1) | 8 (22.9) | 49 (90.7) | 5 (9.3) | 12 (75.0) | 4 (25.0) |
| Pro/Pro | 26 (100) | 0 | 7 (100) | 0 | 7 (100) | 0 | 2 (100) | 0 |
| Genotype | Ischemic stroke | ICH | ||||||
| Cohort 1 (P < 0.0001) | Cohort 2 (P = 0.020) | Cohort 1 (P < 0.0001) | Cohort 2 (P = 0.004) | |||||
| Good prognosis | Poor prognosis | Good prognosis | Poor prognosis | Good prognosis | Poor prognosis | Good prognosis | Poor prognosis | |
| Arg/Arg | 104 (44.3) | 131 (55.7) | 35 (57.4) | 26 (42.6) | 13 (19.4) | 54 (80.6) | 8 (26.7) | 22 (73.3) |
| Arg/Pro | 117 (79.6) | 30 (20.4) | 27 (77.1) | 8 (22.9) | 49 (90.7) | 5 (9.3) | 12 (75.0) | 4 (25.0) |
| Pro/Pro | 26 (100) | 0 | 7 (100) | 0 | 7 (100) | 0 | 2 (100) | 0 |
Cohort 1: patients were admitted at the University Hospital of Santiago de Compostela (Galicia, Spain). Cohort 2: patients were admitted at the University Hospital of Germans Trias i Pujol (Catalonia, Spain). Functional outcome was evaluated at 3 mo using the mRS. An mRS score >2 was considered poor prognosis. Data are numbers (%). Data were compared among genotype groups using the χ2 test.