Table I.

Weekly and total infectious burdens in A2497P− vaccinated and unvaccinated nonhuman primates

Group/monkey number Weeks of infectious burden Total infectious burden 
 1 2 3 4 5 6 7 8 9 10 11 12 13 14  
 IFU IFU IFU IFU IFU IFU IFU IFU IFU IFU IFU IFU IFU IFU IFU 
Vaccinated 
145 222 554 1,082 13 20 0 0 0 0 0 0 0 0 0 1,891 
147 324 376 128 7 7 20 12 3 17 67 19 150 252 166 1,548 
641 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
642 7 0 0 0 0 0 0 0 0 0 0 0 0 0 7 
643 23 1,153 29 0 2 0 0 0 0 0 0 0 0 0 1,207 
647 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
Unvaccinated 
148 86,244 582 318 125 280 31 5 0 0 0 0 97 3 0 87,685 
149 37,186 2,062 226 100 426 117 69 43 61 145 321 290 113 97 41,256 
150 2,911 538 352 209 596 53 15 7 7 0 0 22 0 13 4,723 
644 7,874 24 18 0 3 0 0 13 0 0 0 0 0 0 7,932 
648 23,367 401 25 0 0 0 0 0 0 0 0 0 0 0 23,793 
649 10,885 582 466 26 7 0 10 6 2 23 0 28 37 0 12,072 

The IFU was recovered from conjunctival swabs at weekly intervals after challenge. The total IFU was recovered for all culture time points. The difference between vaccinated and unvaccinated groups in total infectious burden is highly significant (P = 0.0026; Wilcoxon rank-sum test).

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