Weekly and total infectious burdens in A2497P− vaccinated and unvaccinated nonhuman primates
| Group/monkey number | Weeks of infectious burden | Total infectious burden | |||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | ||
| IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | |
| Vaccinated | |||||||||||||||
| 145 | 222 | 554 | 1,082 | 13 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1,891 |
| 147 | 324 | 376 | 128 | 7 | 7 | 20 | 12 | 3 | 17 | 67 | 19 | 150 | 252 | 166 | 1,548 |
| 641 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 642 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| 643 | 23 | 1,153 | 29 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1,207 |
| 647 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Unvaccinated | |||||||||||||||
| 148 | 86,244 | 582 | 318 | 125 | 280 | 31 | 5 | 0 | 0 | 0 | 0 | 97 | 3 | 0 | 87,685 |
| 149 | 37,186 | 2,062 | 226 | 100 | 426 | 117 | 69 | 43 | 61 | 145 | 321 | 290 | 113 | 97 | 41,256 |
| 150 | 2,911 | 538 | 352 | 209 | 596 | 53 | 15 | 7 | 7 | 0 | 0 | 22 | 0 | 13 | 4,723 |
| 644 | 7,874 | 24 | 18 | 0 | 3 | 0 | 0 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 7,932 |
| 648 | 23,367 | 401 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 23,793 |
| 649 | 10,885 | 582 | 466 | 26 | 7 | 0 | 10 | 6 | 2 | 23 | 0 | 28 | 37 | 0 | 12,072 |
| Group/monkey number | Weeks of infectious burden | Total infectious burden | |||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | ||
| IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | IFU | |
| Vaccinated | |||||||||||||||
| 145 | 222 | 554 | 1,082 | 13 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1,891 |
| 147 | 324 | 376 | 128 | 7 | 7 | 20 | 12 | 3 | 17 | 67 | 19 | 150 | 252 | 166 | 1,548 |
| 641 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 642 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| 643 | 23 | 1,153 | 29 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1,207 |
| 647 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Unvaccinated | |||||||||||||||
| 148 | 86,244 | 582 | 318 | 125 | 280 | 31 | 5 | 0 | 0 | 0 | 0 | 97 | 3 | 0 | 87,685 |
| 149 | 37,186 | 2,062 | 226 | 100 | 426 | 117 | 69 | 43 | 61 | 145 | 321 | 290 | 113 | 97 | 41,256 |
| 150 | 2,911 | 538 | 352 | 209 | 596 | 53 | 15 | 7 | 7 | 0 | 0 | 22 | 0 | 13 | 4,723 |
| 644 | 7,874 | 24 | 18 | 0 | 3 | 0 | 0 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 7,932 |
| 648 | 23,367 | 401 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 23,793 |
| 649 | 10,885 | 582 | 466 | 26 | 7 | 0 | 10 | 6 | 2 | 23 | 0 | 28 | 37 | 0 | 12,072 |
The IFU was recovered from conjunctival swabs at weekly intervals after challenge. The total IFU was recovered for all culture time points. The difference between vaccinated and unvaccinated groups in total infectious burden is highly significant (P = 0.0026; Wilcoxon rank-sum test).