NP, no polymorphism. Genes listed are found in the 117-kb interval. The Exon/nucleotide column indicates SNPs found in exons. The exon number and the position of the SNP in the cDNA of the gene are given. The Protein column indicates the effect of the SNP (p.= indicates a synonymous mutation without effect on the primary structure of the protein; when the SNP is nonsynonymous, the position and the amino acid substitution according to the nucleotide mutation are given). Genotypes of BN type or similar to BN genotype are in bold. Mean percentages ± SEM of CD4⁺Foxp3⁺ T cells in PBMCs (n ≥ 4) are as follows: BN, 17.0 ± 0.2%; LEW, 8.9 ± 0.9%; Bf, 11.1 ± 0.5%; DA, 10.3 ± 0.3%; PVG, 7.6 ± 0.2%; BB, 11.0 ± 0.2%; and ACI, 9.9 ± 0.5%.

This mutation in the first exon of Vav1 is the only mutation associated with the high (BN genotype) or low (other strains genotypes) percentage of CD4⁺Foxp3⁺ T cells.

BN.LEWc9-Bf congenic line.