Table II. Mutations within CD81 binding... | Rockefeller University Press

Table II.

Mutations within CD81 binding domains of viral variants

Viral variants	CD81 BDI amino acid positions				CD81 BDII amino acid positions									CD81 BDIII amino acid positions
	412	414	416	420	474	475	476	477	478	479	480	481	492	521	522	524	528	531	533	537	538
P01VL^a	Q	V	T	W	Y	A	E	S	R	S	S	D	Q	R	S	V	T	E	K	L	L
P01VA^a
P01VB^b
P01VC^b									C				K
P01VI^b															L
P01VK^b								P			L				F			A	E
P01VJ^c		I						P					R		L
P02VI^a	Q	I	T	W	Y	A	E	P	H	D	L	G	Q	R	S	A	N	E	E	L	I
P02VJ^a									Q			D	R
P02VH^a									Q			D	R
P02VA^a		V										D
P02VD^a		V										D	R
P02VB^b				L						A		D
P02VF^c			S						R		S	D	R
P02VG^c		V										D	R			T
P03VC^a	K	V	T	W	Y	A	K	P	N	S	S	D	R	R	F	A	S	E	E	L	L
P03VA^a	Q						E		T
P03VB^b							E
P04VE^a	Q	I	T	W	Y	A	E	P	R	S	L	D	Q	R	F	V	N	E	E	L	L
P04VD^a
P04VC^b
P04VA^b										N				K
P04VB^b
P05VE^a	Q	V	T	W	Y	T	E	P	E	A	L	D	Q	R	F	V	S	E	E	L	L
P05VF^a
P05VD^a
P05VA^c
P05VB^c
P05VC^c
P06VH^a	Q	I	T	W	H	V	V	P	H	G	L	D	R	R	F	A	T	E	E	F	I
P06VI^a									R
P06VD^a													Q
P06VG^b						A			R
P06VF^b					Y	A	E	S	R	S						V	N			L	L
P06VA^c					Y	A	E		R	S
P06VB^c					Y	A	E		R	S						V	N			L	L
P06VC^c

Viral variants	CD81 BDI amino acid positions				CD81 BDII amino acid positions									CD81 BDIII amino acid positions
	412	414	416	420	474	475	476	477	478	479	480	481	492	521	522	524	528	531	533	537	538
P01VL^a	Q	V	T	W	Y	A	E	S	R	S	S	D	Q	R	S	V	T	E	K	L	L
P01VA^a
P01VB^b
P01VC^b									C				K
P01VI^b															L
P01VK^b								P			L				F			A	E
P01VJ^c		I						P					R		L
P02VI^a	Q	I	T	W	Y	A	E	P	H	D	L	G	Q	R	S	A	N	E	E	L	I
P02VJ^a									Q			D	R
P02VH^a									Q			D	R
P02VA^a		V										D
P02VD^a		V										D	R
P02VB^b				L						A		D
P02VF^c			S						R		S	D	R
P02VG^c		V										D	R			T
P03VC^a	K	V	T	W	Y	A	K	P	N	S	S	D	R	R	F	A	S	E	E	L	L
P03VA^a	Q						E		T
P03VB^b							E
P04VE^a	Q	I	T	W	Y	A	E	P	R	S	L	D	Q	R	F	V	N	E	E	L	L
P04VD^a
P04VC^b
P04VA^b										N				K
P04VB^b
P05VE^a	Q	V	T	W	Y	T	E	P	E	A	L	D	Q	R	F	V	S	E	E	L	L
P05VF^a
P05VD^a
P05VA^c
P05VB^c
P05VC^c
P06VH^a	Q	I	T	W	H	V	V	P	H	G	L	D	R	R	F	A	T	E	E	F	I
P06VI^a									R
P06VD^a													Q
P06VG^b						A			R
P06VF^b					Y	A	E	S	R	S						V	N			L	L
P06VA^c					Y	A	E		R	S
P06VB^c					Y	A	E		R	S						V	N			L	L
P06VC^c

BD, binding domain; RLU, relative light unit. For each patient, amino acid changes in the CD81 BDI, BDII, and BDIII (Owsianka et al., 2006) relative to the most prevalent variant showing efficient viral entry are indicated. Amino acid positions where at least one mutation was observed in the six patients are shown; conserved amino acid positions are not depicted.

Variants showing high infectivity (RLU ≥ 5 log₁₀).

Variants showing low infectivity (5 log ₁₀ ≥ RLU ≤ 3.5 log₁₀).

Noninfectious variants (RLU ≤ 3 log₁₀).

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