Cytokine production by human PBMCs treated with 100 nM GW0742
| Stimulus | Donor 1 | Donor 2 | Donor 3 | |||
| Vehicle | GW0742 | Vehicle | GW0742 | Vehicle | GW0742 | |
| α-CD3 and α-CD28 | ||||||
| IL-2 | 122 (7) | 160 (8)a | 178 (5) | 200 (11) | 92 (11) | 93 (4) |
| IL-17A | 21 (2) | 25 (1) | 14 (1) | 16 (5) | 16 (1) | 14 (1) |
| TNF | 140 (12) | 113 (13) | 491 (17) | 400 (88) | 1,019 (50) | 1,178 (50) |
| IFN-γ | 1,231 (213) | 716 (33)a | 4,205 (129) | 3,125 (271)a | 3,087 (111) | 2,547 (97)a |
| LPS | ||||||
| IL-12p40 | 7,160 (152) | 4,541 (162)a | 5,497 (264) | 3,203 (328)a | 8,881 (367) | 5,562 (318)a |
| IL-23 | 3,581 (54) | 2,507 (109)a | 2,262 (41) | 1,450 (50)a | 3,775 (136) | 2,508 (124)a |
| IL-12p70 | 322 (38) | 275 (36) | 1,486 (145) | 991 (85) a | 1,195 (187) | 1,335 (157) |
| Stimulus | Donor 1 | Donor 2 | Donor 3 | |||
| Vehicle | GW0742 | Vehicle | GW0742 | Vehicle | GW0742 | |
| α-CD3 and α-CD28 | ||||||
| IL-2 | 122 (7) | 160 (8)a | 178 (5) | 200 (11) | 92 (11) | 93 (4) |
| IL-17A | 21 (2) | 25 (1) | 14 (1) | 16 (5) | 16 (1) | 14 (1) |
| TNF | 140 (12) | 113 (13) | 491 (17) | 400 (88) | 1,019 (50) | 1,178 (50) |
| IFN-γ | 1,231 (213) | 716 (33)a | 4,205 (129) | 3,125 (271)a | 3,087 (111) | 2,547 (97)a |
| LPS | ||||||
| IL-12p40 | 7,160 (152) | 4,541 (162)a | 5,497 (264) | 3,203 (328)a | 8,881 (367) | 5,562 (318)a |
| IL-23 | 3,581 (54) | 2,507 (109)a | 2,262 (41) | 1,450 (50)a | 3,775 (136) | 2,508 (124)a |
| IL-12p70 | 322 (38) | 275 (36) | 1,486 (145) | 991 (85) a | 1,195 (187) | 1,335 (157) |
Values are means + SEM of cytokine levels (pg/ml) in triplicate cultures.
Significant difference from vehicle control cultures using a Student’s t test (P = 0.05, two-tailed).