Table 2.
Mechanisms increasing ipRGCs’ or reducing conventional RGCs’ final-to-peak photoresponse ratios
MechanismipRGCsTRHR+ RGCsHoxd10+ ON RGCsHoxd10+ ON-OFF RGCs
Center/surround antagonism   X  
Spike frequency adaptation     
Regulation of spiking by resting potential X  X  
Intracellular Ca2+     
Melanopsin  Not tested Not tested Not tested 
Tonic versus transient bipolar input X X X X 
Presence or absence of presynaptic inhibition X X  X 
Dopaminergic modulation  X   
AMPA/kainate receptor desensitization     
NMDA receptors  Not tested Not tested Not tested 
mGluR7 on presynaptic bipolar cell terminals X    
Glutamate uptake by transporters     
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