Table 2.
Mechanisms increasing ipRGCs’ or reducing conventional RGCs’ final-to-peak photoresponse ratios
MechanismipRGCsTRHR+ RGCsHoxd10+ ON RGCsHoxd10+ ON-OFF RGCs
Center/surround antagonism    
Spike frequency adaptation     
Regulation of spiking by resting potential   
Intracellular Ca2+     
Melanopsin  Not tested Not tested Not tested 
Tonic versus transient bipolar input 
Presence or absence of presynaptic inhibition  
Dopaminergic modulation    
AMPA/kainate receptor desensitization     
NMDA receptors  Not tested Not tested Not tested 
mGluR7 on presynaptic bipolar cell terminals    
Glutamate uptake by transporters     
MechanismipRGCsTRHR+ RGCsHoxd10+ ON RGCsHoxd10+ ON-OFF RGCs
Center/surround antagonism    
Spike frequency adaptation     
Regulation of spiking by resting potential   
Intracellular Ca2+     
Melanopsin  Not tested Not tested Not tested 
Tonic versus transient bipolar input 
Presence or absence of presynaptic inhibition  
Dopaminergic modulation    
AMPA/kainate receptor desensitization     
NMDA receptors  Not tested Not tested Not tested 
mGluR7 on presynaptic bipolar cell terminals    
Glutamate uptake by transporters     

or Create an Account

Close Modal
Close Modal