Activation rate and equilibrium constants for wt AChRs
| Agonists | kon | koff | Kd | Concentrations |
| mM−1s−1 | s−1 | M | mM | |
| DMP | 1,383 | 2,838 | 2.1 E-3 | 1, 2, 3 |
| DMT | 1,991 | 3,194 | 1.6 E-3 | 1, 2, 3 |
| Nic | 2,484 | 2,501 | 1 E-3 | 1, 2, 3 |
| TMA | 6,770 | 5,515 | 0.81 E-3 | 0.3, 0.5, 0.7 |
| CCh | 17,500 | 7,178 | 0.41 E-3 | 0.1, 0.2, 0.3, 0.5 |
| ACh | 106,108 | 17,614 | 0.16 E-3 | 0.03, 0.1, 0.3 |
| Agonists | kon | koff | Kd | Concentrations |
| mM−1s−1 | s−1 | M | mM | |
| DMP | 1,383 | 2,838 | 2.1 E-3 | 1, 2, 3 |
| DMT | 1,991 | 3,194 | 1.6 E-3 | 1, 2, 3 |
| Nic | 2,484 | 2,501 | 1 E-3 | 1, 2, 3 |
| TMA | 6,770 | 5,515 | 0.81 E-3 | 0.3, 0.5, 0.7 |
| CCh | 17,500 | 7,178 | 0.41 E-3 | 0.1, 0.2, 0.3, 0.5 |
| ACh | 106,108 | 17,614 | 0.16 E-3 | 0.03, 0.1, 0.3 |
Concentrations are those used for the estimation of Kd. In all cases, the SEM of the rate constants were <10% of the optimal values shown. kon, koff, agonist association and dissociation rate constants to resting receptors; Kd (=koff/kon), the LA agonist equilibrium dissociation constant to resting receptors; Jd, the HA agonist equilibrium dissociation constant to open-channel (R*) receptors.