Table I.

Distinctive chemical features of cholesterol and analogs

Trivial name IUPAC nomenclature 3-OH orientation A/B junction 
Cholesterol (3S, 10R, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol β n/aa 
Epicholesterol (3R, 10R, 13R, 17R)-10, 13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol α n/aa 
Coprostanol (3S, 5R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol β cis 
Epicoprostanol (3R, 5R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol α cis 
Cholestanol (3S, 5S, 8R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol β trans 
Epicholestanol (3R, 5S, 8R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol α trans 
Ent-cholesterol (3R,8R,9R,10S,13S,14R,17S)-10,13-dimethyl-17-((S)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol β n/aa 
Trivial name IUPAC nomenclature 3-OH orientation A/B junction 
Cholesterol (3S, 10R, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol β n/aa 
Epicholesterol (3R, 10R, 13R, 17R)-10, 13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol α n/aa 
Coprostanol (3S, 5R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol β cis 
Epicoprostanol (3R, 5R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol α cis 
Cholestanol (3S, 5S, 8R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol β trans 
Epicholestanol (3R, 5S, 8R, 9S, 10S, 13R, 14S, 17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol α trans 
Ent-cholesterol (3R,8R,9R,10S,13S,14R,17S)-10,13-dimethyl-17-((S)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol β n/aa 
a

Because of the presence of the double bond at C5–C6 (Fig.1), the A/B junction presents neither cis nor trans geometry.

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