Electrophysiological parameters of wild-type and TASK-null mouse glomus cells
| Parameter | Wild type | Task1−/− | Task1/3−/− |
| Cell capacitance (pF) | 2.9 ± 0.1 (25) | 2.7 ± 0.1 (29) | 2.9 ± 0.1 (28) |
| Input resistance (GOhm) | 7.8 ± 0.9 (25) | 8.4 ± 0.8 (29) | 10.8 ± 0.9* (31) |
| Membrane potential (mV) | −57.0 ± 1.2 (24) | −54.5 ± 1.8 (29) | −51.5 ± 0.8* (33) |
| Current density (−20 mV, pH 8.2, pA/pF) | 7.9 ± 2.7 (13) | — | 1.6 ± 0.5* (14) |
| Peak K+ current (+30 mV, pA/pF) | 362 ± 17 (13) | 390 ± 21 (11) | 262 ± 17** (21) |
| Peak Na+ current (+10 mV, pA/pF) | −26.2 ± 5.0 (11) | −24.5 ± 5.2 (12) | −27.5 ± 3.4 (22) |
| Peak Ca2+ current (+20 mV, pA/pF) | −7.5 ± 0.9 (21) | −9.1 ± 1.9 (12) | −3.3 ± 0.4** (33) |
| Parameter | Wild type | Task1−/− | Task1/3−/− |
| Cell capacitance (pF) | 2.9 ± 0.1 (25) | 2.7 ± 0.1 (29) | 2.9 ± 0.1 (28) |
| Input resistance (GOhm) | 7.8 ± 0.9 (25) | 8.4 ± 0.8 (29) | 10.8 ± 0.9* (31) |
| Membrane potential (mV) | −57.0 ± 1.2 (24) | −54.5 ± 1.8 (29) | −51.5 ± 0.8* (33) |
| Current density (−20 mV, pH 8.2, pA/pF) | 7.9 ± 2.7 (13) | — | 1.6 ± 0.5* (14) |
| Peak K+ current (+30 mV, pA/pF) | 362 ± 17 (13) | 390 ± 21 (11) | 262 ± 17** (21) |
| Peak Na+ current (+10 mV, pA/pF) | −26.2 ± 5.0 (11) | −24.5 ± 5.2 (12) | −27.5 ± 3.4 (22) |
| Peak Ca2+ current (+20 mV, pA/pF) | −7.5 ± 0.9 (21) | −9.1 ± 1.9 (12) | −3.3 ± 0.4** (33) |
Recordings were performed using perforated patches with the exception of those done to measure macroscopic voltage-dependent K+, Na+, and Ca2+ current density, in which we used whole cell (dialyzed) patch-clamped cells. Values are given as mean ± SE, with the number of experiments in parentheses. Asterisks indicate statistical significance (*, P < 0.05; **, P < 0.01) with respect to corresponding values in wild-type cells.