Parameters of RYR gating
| Parameter | HTG | aHTG | Comments |
| KCa (µM) | 1.36 | 0.6 | Zahradník et al., 2005 |
| KMg (μM) | 431 ± 12 | 79 ± 8 | Fitted parameter |
| fCa | N/A | 0.046 | Zahradník et al., 2005 |
| fMg | N/A | 1.40 ± 0.05 | Fitted parameter |
| KO00 | N/A | 10,800 | Zahradník et al., 2005 |
| KO40 | 0.00219 | N/A | Zahradník et al., 2005 |
| KOL | 0.5 | 0.5 | Zahradník et al., 2005 |
| KCL | 0.0333 | 0.89 | Zahradník et al., 2005 |
| KCI | 3.0 | 3.0 | Zahradník et al., 2005 |
| KI (μM) | 760 | 760 | Zahradníková et al., 2003 |
| [Mg] (mM) | 1.0 | 1.0 | Lukyanenko and Györke, 1999 |
| Parameter | HTG | aHTG | Comments |
| KCa (µM) | 1.36 | 0.6 | Zahradník et al., 2005 |
| KMg (μM) | 431 ± 12 | 79 ± 8 | Fitted parameter |
| fCa | N/A | 0.046 | Zahradník et al., 2005 |
| fMg | N/A | 1.40 ± 0.05 | Fitted parameter |
| KO00 | N/A | 10,800 | Zahradník et al., 2005 |
| KO40 | 0.00219 | N/A | Zahradník et al., 2005 |
| KOL | 0.5 | 0.5 | Zahradník et al., 2005 |
| KCL | 0.0333 | 0.89 | Zahradník et al., 2005 |
| KCI | 3.0 | 3.0 | Zahradník et al., 2005 |
| KI (μM) | 760 | 760 | Zahradníková et al., 2003 |
| [Mg] (mM) | 1.0 | 1.0 | Lukyanenko and Györke, 1999 |
The corresponding gating schemes are shown in the supplemental material. N/A, not applicable. KCa, calcium dissociation constant of the ion-free closed state C00. KMg, magnesium dissociation constant of the ion-free closed state C00. KO00, dissociation constant of the ion-free open state O00. KO40, dissociation constant of the open state O40. fCa, allosteric factor coupling calcium binding to channel opening. fMg, allosteric factor coupling magnesium binding to channel opening. KOL, dissociation constant of the L-mode open state OL. KCL, dissociation constant of the L-mode closed state CL. KCI, dissociation constant of the inactivated state I. KI, inhibitory constant of Mg2+ ions at the divalent inhibitory site. [Mg], free Mg2+ concentration.