Table VI. Simulated versus experimental... | Rockefeller University Press

Table VI.

Simulated versus experimental ensemble current parameters

			Deactivation				PP(% of first peak)
Channel	Mechanism	10–90% RT (ms)	τ₁ (ms)	A₁	τ₂ (ms)	A₂	PP(% of first peak)
α₁β₂γ_2S	S1	1.07	10.0	0.90	89.0	0.10	98
	S1 (ϕ₊₁ = 1,250)	0.96	12.6	0.84	75.6	0.16	92
	S2	0.20	5.77	0.44	–	–	99
	S4	1.35	7.85	0.22	21.1	0.78	116
	Experimental	0.65^a	8.60 ± 0.81^b	0.91± 0.01^b	88.3 ± 4.7^b	0.09 ± 0.02^b	0.96 ± 0.04^c
α₃β₃γ_2S	S1	1.65	72.2	0.98	229	0.02	123
	S2	0.84	25.4	0.98	101	0.02	113
	S4	1.53	14.2	0.23	52.6	0.77	123
	Experimental	1.60 ± 0.28^d	∼10–70^e	∼0.45^e	∼170–450^e	∼0.55^e	122^f

			Deactivation				PP(% of first peak)
Channel	Mechanism	10–90% RT (ms)	τ₁ (ms)	A₁	τ₂ (ms)	A₂	PP(% of first peak)
α₁β₂γ_2S	S1	1.07	10.0	0.90	89.0	0.10	98
	S1 (ϕ₊₁ = 1,250)	0.96	12.6	0.84	75.6	0.16	92
	S2	0.20	5.77	0.44	–	–	99
	S4	1.35	7.85	0.22	21.1	0.78	116
	Experimental	0.65^a	8.60 ± 0.81^b	0.91± 0.01^b	88.3 ± 4.7^b	0.09 ± 0.02^b	0.96 ± 0.04^c
α₃β₃γ_2S	S1	1.65	72.2	0.98	229	0.02	123
	S2	0.84	25.4	0.98	101	0.02	113
	S4	1.53	14.2	0.23	52.6	0.77	123
	Experimental	1.60 ± 0.28^d	∼10–70^e	∼0.45^e	∼170–450^e	∼0.55^e	122^f

Interpolated from activation plot at 5 mM GABA in Keramidas and Harrison (2008).

n = 6.

24-ms interpulse interval; n = 16.

At 5 mM GABA; n = 3.

Values obtained from Mozrzymas et al. (2007) and Schofield and Huguenard (2007).

25-ms interpulse interval (Schofield and Huguenard, 2007).

RT, rise time; PP, paired-pulse.