Table II. Summary of the values of... | Rockefeller University Press

Table II.

Summary of the values of passive force, maximal active force, pCa₅₀, and n_H in PLV with and without pimobendan

	SL	Passive force	Maximal force	pCa₅₀	ΔpCa₅₀	n_H
	μm	mN/mm²	mN/mm²
Without sTn reconstitution
Vehicle	1.9	∼0	55.58 ± 3.97	5.55 ± 0.01		3.72 ± 0.14
	2.3	8.90 ± 0.52	76.68 ± 2.94	5.77 ± 0.01	0.22 ± 0.01	3.21 ± 0.04
+Pimobendan	1.9	∼0	44.98 ± 3.76	5.77 ± 0.03^a		2.87 ± 0.13^a
	2.3	8.74 ± 1.04	61.81 ± 5.92	5.97 ± 0.02^a	0.20 ± 0.02	2.53 ± 0.25^a
With sTn reconstitution
Vehicle	1.9	∼0	53.68 ± 3.47	5.80 ± 0.01^a		3.29 ± 0.07^a
	2.3	8.88 ± 0.36	59.96 ± 3.15^a	5.93 ± 0.01^a	0.14 ± 0.01^a	3.45 ± 0.11
+Pimobendan	1.9	∼0	51.52 ± 2.14	5.82 ± 0.01^a		3.68 ± 0.13
	2.3	9.37 ± 1.03	60.15 ± 3.55^a	5.96 ± 0.01^a	0.14 ± 0.01^a	3.82 ± 0.19^a

	SL	Passive force	Maximal force	pCa₅₀	ΔpCa₅₀	n_H
	μm	mN/mm²	mN/mm²
Without sTn reconstitution
Vehicle	1.9	∼0	55.58 ± 3.97	5.55 ± 0.01		3.72 ± 0.14
	2.3	8.90 ± 0.52	76.68 ± 2.94	5.77 ± 0.01	0.22 ± 0.01	3.21 ± 0.04
+Pimobendan	1.9	∼0	44.98 ± 3.76	5.77 ± 0.03^a		2.87 ± 0.13^a
	2.3	8.74 ± 1.04	61.81 ± 5.92	5.97 ± 0.02^a	0.20 ± 0.02	2.53 ± 0.25^a
With sTn reconstitution
Vehicle	1.9	∼0	53.68 ± 3.47	5.80 ± 0.01^a		3.29 ± 0.07^a
	2.3	8.88 ± 0.36	59.96 ± 3.15^a	5.93 ± 0.01^a	0.14 ± 0.01^a	3.45 ± 0.11
+Pimobendan	1.9	∼0	51.52 ± 2.14	5.82 ± 0.01^a		3.68 ± 0.13
	2.3	9.37 ± 1.03	60.15 ± 3.55^a	5.96 ± 0.01^a	0.14 ± 0.01^a	3.82 ± 0.19^a

Data are for Fig. 6. Maximal force was obtained by activating muscle at pCa 4.5 before construction of the force–pCa curve at each SL (passive force was measured just before activation at pCa 4.5). Maximal force obtained before sTn reconstitution: 56.06 ± 3.42 and 54.25 ± 2.20 mN/mm² for vehicle and pimobendan-treated group, respectively (P > 0.05 compared with the value obtained after sTn reconstitution). Pimobendan did not significantly change maximal force (see Fukuda et al., 2000) with and without sTn reconstitution, and it did not change any parameter in sTn-reconstituted muscles.

P < 0.05 compared with the corresponding values in the vehicle-treated group without sTn reconstitution.

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