Table IV Summary of Charge... | Rockefeller University Press

Table IV

Summary of Charge Neutralization Mutation Effects on Fast Inactivation

Channel	v_1/2 shift^*	a_h change^*
	mV
1R1Q^‡	−0.8	−0.2
1R1Q^§	−5.0	−0.8
1R2Q	−5.1^‖	−1.0^‖
1R2Q^§	−6.0	−0.5
1R3Q^‡	−5.8	−1.1^‖
1R3Q^§	+6.0	+1.4
1K4Q	−3.7^‖	−0.4^‖
1K4Q^§	−6.0	+0.9
2R1Q^‡	+8.2^‖	−0.4
2R2Q	−8.1^‖	−0.8^‖
2R3Q^‡	−9.6^‖	−1.1^‖
2K4Q	−5.7^‖	−0.6^‖
2K5Q^§	−9.0	−0.8
3K1Q^‡	−21.0^‖	−0.8^‖
3R2Q	−8.5^‖	−0.9^‖
3R3Q^‡	−10.6^‖	−0.6
3R4Q	−3.2^‖	0.0
4R0Q^‡	+4.7^‖	−2.0^‖
4R2Q	−0.6	−0.5^‖
4R2Q^‡	−57.5^‖	−2.6^‖
4R4Q	+0.2	+0.3

Channel	v_1/2 shift^*	a_h change^*
	mV
1R1Q^‡	−0.8	−0.2
1R1Q^§	−5.0	−0.8
1R2Q	−5.1^‖	−1.0^‖
1R2Q^§	−6.0	−0.5
1R3Q^‡	−5.8	−1.1^‖
1R3Q^§	+6.0	+1.4
1K4Q	−3.7^‖	−0.4^‖
1K4Q^§	−6.0	+0.9
2R1Q^‡	+8.2^‖	−0.4
2R2Q	−8.1^‖	−0.8^‖
2R3Q^‡	−9.6^‖	−1.1^‖
2K4Q	−5.7^‖	−0.6^‖
2K5Q^§	−9.0	−0.8
3K1Q^‡	−21.0^‖	−0.8^‖
3R2Q	−8.5^‖	−0.9^‖
3R3Q^‡	−10.6^‖	−0.6
3R4Q	−3.2^‖	0.0
4R0Q^‡	+4.7^‖	−2.0^‖
4R2Q	−0.6	−0.5^‖
4R2Q^‡	−57.5^‖	−2.6^‖
4R4Q	+0.2	+0.3

v_1/2 and a_h are the half-maximal voltage and slope factor for fast inactivation. Data from Stühmer et al. (1989) did not include an assessment of statistical significance.

‡

Data from Chen et al. (1966).

Data from Stühmer et al. (1989). These data were acquired using a 100-ms prepulse, whereas all other data were acquired using a 500-ms prepulse.

‖

Values statistically significant, with a probability <0.05 resulting from random variation.

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