Table IV Summary of Charge-neutralizing... | Rockefeller University Press

Table IV

Summary of Charge-neutralizing Mutation Effects on Activation

Mutant	v_1/2 shift^*	z_m change (e₀)^*
	mV
1R1Q^‡	+3.3	−0.6
1R1Q^§	−2.0	0.0
1R2Q	−1.0	+0.4
1R2Q^§	−8.0	−1.8^‖
1R3Q^‡	+4.7¹⁷⁶	−1.7¹⁷⁶
1R3Q^§	+12.0	−1.5^‖
1K4Q	+18.5¹⁷⁶	−1.2¹⁷⁶
1K4Q^§	+19.0	−0.9^‖
2R1Q^‡	+13.3¹⁷⁶	−1.2¹⁷⁶
2R2Q	+4.4¹⁷⁶	−1.1¹⁷⁶
2R3Q^‡	+0.4¹⁷⁶	−1.6¹⁷⁶
2K4Q	+14.9¹⁷⁶	−0.7
2K5Q^§	+10.0	0.0
3K1Q^‡	−10.4¹⁷⁶	−0.5
3R2Q	−0.3	+0.4
3R3Q^‡	+5.9¹⁷⁶	−2.1¹⁷⁶
3R4Q	−18.1¹⁷⁶	+0.3
4R0Q^‡	+2.3	−1.6¹⁷⁶
4R2Q	+3.6¹⁷⁶	−0.5
4R2Q^‡	+8.6¹⁷⁶	−1.6¹⁷⁶
4R4Q	+0.4	+0.9

Mutant	v_1/2 shift^*	z_m change (e₀)^*
	mV
1R1Q^‡	+3.3	−0.6
1R1Q^§	−2.0	0.0
1R2Q	−1.0	+0.4
1R2Q^§	−8.0	−1.8^‖
1R3Q^‡	+4.7¹⁷⁶	−1.7¹⁷⁶
1R3Q^§	+12.0	−1.5^‖
1K4Q	+18.5¹⁷⁶	−1.2¹⁷⁶
1K4Q^§	+19.0	−0.9^‖
2R1Q^‡	+13.3¹⁷⁶	−1.2¹⁷⁶
2R2Q	+4.4¹⁷⁶	−1.1¹⁷⁶
2R3Q^‡	+0.4¹⁷⁶	−1.6¹⁷⁶
2K4Q	+14.9¹⁷⁶	−0.7
2K5Q^§	+10.0	0.0
3K1Q^‡	−10.4¹⁷⁶	−0.5
3R2Q	−0.3	+0.4
3R3Q^‡	+5.9¹⁷⁶	−2.1¹⁷⁶
3R4Q	−18.1¹⁷⁶	+0.3
4R0Q^‡	+2.3	−1.6¹⁷⁶
4R2Q	+3.6¹⁷⁶	−0.5
4R2Q^‡	+8.6¹⁷⁶	−1.6¹⁷⁶
4R4Q	+0.4	+0.9

v_1/2 and z_m are the half-maximal voltage and gating valence of activation. Data from Stühmer et al. (1989) did not include an assessment of statistical significance.

‡

Data from Chen et al. (1996).

Data from Stühmer et al. (1989).

‖

The values for z_m from Stühmer et al. (1989) were multiplied by three for comparison because those values were based on three identical gating charges (m³).

176

Values statistically significant, with a probability <0.05 resulting from random variation.

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