Table I. Genes differentially expressed... | Rockefeller University Press

Table I.

Genes differentially expressed between NLPHL and cHL

	FC	Gene symbol	Affymetrix probe set ID	Gene name
Genes up-regulated in cHL compared with NLPHL
	33.6	CCL22	207861_at	chemokine (c-c motif) ligand 22; MDC
	15.6	CCL17	207900_at	chemokine (c-c motif) ligand 17; TARC
	7.2	SNFT	220358_at	Jun dimerization protein p21SNFT
	4	ODZ2	231867_at	odz, odd Oz/ten-m homolog 2 (Drosophila); teneurin-2
	3.1	IL6	205207_at	IL-6 (IFN, β 2)
	2.3	MGST3	201403_s_at	microsomal glutathione S-transferase 3
Genes up-regulated in NLPHL compared with cHL (and GC B cells)
	4.9	KISS1R	242517_at	KISS1 receptor; GPR54
	3.9	CHIT1	208168_s_at	chitinase 1 (chitotriosidase)
	3.9/2.9	GBP1	231577_s_at	guanylate binding protein 1, IFN-inducible, 67 kD
			202269_x_at
	3.8	SGK	201739_at	serum/glucocorticoid-regulated kinase
	3.2	CHI3L1	209396_s_at	chitinase 3-like 1 (cartilage glycoprotein-39)
	2.9	SLAMF7	222838_at	SLAM family member 7
	2.9	GLA	214430_at	galactosidase, α
	2.9	TSC22D1	215111_s_at	TSC22 domain family, member 1
	2.8	STAT1	AFFX-HUMISGF3A/ M97935_3_at	signal transducer and activator of transcription 1, 91 kD
	2.8	EOMES	231776_at	eomesodermin homolog (Xenopus laevis)
	2.8	ITM2A	202747_s_at	integral membrane protein 2A
	2.6	TMEM163	223503_at	transmembrane protein 163
	2.6	ATP6V1A	201972_at	ATPase, H⁺ transporting, lysosomal 70 kD, V1 subunit A
	2.5	PLXNA1	221538_s_at	plexin A1
	2.4	DRAM	218627_at	damage-regulated autophagy modulator
	2.4	DUSP2	204794_at	Dual-specific phosphatase 2; PAC1
	2.4	PLEK	203471_s_at	pleckstrin
	2.3	CKS2	204170_s_at	CDC28 protein kinase regulatory subunit 2
	2.3	PRKCZ	202178_at	protein kinase C, ζ
	2.3	LIMS1	212687_at	LIM and senescent cell antigen-like domains 1
	2.2	F11R	223000_s_at	F11 receptor
	2.2	SLC31A1	203971_at	solute carrier family 31 (copper transporters), member 1
	2.1	CTSH	202295_s_at	cathepsin H
	2.1	BID	211725_s_at	BH3 interacting domain death agonist
	2.1	NOD27	226474_at	nucleotide-binding oligomerization domains 27
	1.8	RAB27A	210951_x_at	RAB27A, member RAS oncogene family
	1.8	PSMB8	209040_s_at	proteasome (prosome, macropain) subunit, β type, 8 (large multifunctional peptidase 7)

	FC	Gene symbol	Affymetrix probe set ID	Gene name
Genes up-regulated in cHL compared with NLPHL
	33.6	CCL22	207861_at	chemokine (c-c motif) ligand 22; MDC
	15.6	CCL17	207900_at	chemokine (c-c motif) ligand 17; TARC
	7.2	SNFT	220358_at	Jun dimerization protein p21SNFT
	4	ODZ2	231867_at	odz, odd Oz/ten-m homolog 2 (Drosophila); teneurin-2
	3.1	IL6	205207_at	IL-6 (IFN, β 2)
	2.3	MGST3	201403_s_at	microsomal glutathione S-transferase 3
Genes up-regulated in NLPHL compared with cHL (and GC B cells)
	4.9	KISS1R	242517_at	KISS1 receptor; GPR54
	3.9	CHIT1	208168_s_at	chitinase 1 (chitotriosidase)
	3.9/2.9	GBP1	231577_s_at	guanylate binding protein 1, IFN-inducible, 67 kD
			202269_x_at
	3.8	SGK	201739_at	serum/glucocorticoid-regulated kinase
	3.2	CHI3L1	209396_s_at	chitinase 3-like 1 (cartilage glycoprotein-39)
	2.9	SLAMF7	222838_at	SLAM family member 7
	2.9	GLA	214430_at	galactosidase, α
	2.9	TSC22D1	215111_s_at	TSC22 domain family, member 1
	2.8	STAT1	AFFX-HUMISGF3A/ M97935_3_at	signal transducer and activator of transcription 1, 91 kD
	2.8	EOMES	231776_at	eomesodermin homolog (Xenopus laevis)
	2.8	ITM2A	202747_s_at	integral membrane protein 2A
	2.6	TMEM163	223503_at	transmembrane protein 163
	2.6	ATP6V1A	201972_at	ATPase, H⁺ transporting, lysosomal 70 kD, V1 subunit A
	2.5	PLXNA1	221538_s_at	plexin A1
	2.4	DRAM	218627_at	damage-regulated autophagy modulator
	2.4	DUSP2	204794_at	Dual-specific phosphatase 2; PAC1
	2.4	PLEK	203471_s_at	pleckstrin
	2.3	CKS2	204170_s_at	CDC28 protein kinase regulatory subunit 2
	2.3	PRKCZ	202178_at	protein kinase C, ζ
	2.3	LIMS1	212687_at	LIM and senescent cell antigen-like domains 1
	2.2	F11R	223000_s_at	F11 receptor
	2.2	SLC31A1	203971_at	solute carrier family 31 (copper transporters), member 1
	2.1	CTSH	202295_s_at	cathepsin H
	2.1	BID	211725_s_at	BH3 interacting domain death agonist
	2.1	NOD27	226474_at	nucleotide-binding oligomerization domains 27
	1.8	RAB27A	210951_x_at	RAB27A, member RAS oncogene family
	1.8	PSMB8	209040_s_at	proteasome (prosome, macropain) subunit, β type, 8 (large multifunctional peptidase 7)

129 genes are differentially expressed between L&H and HRS using ≥1.8 as the FC cut-off, and a t test p-value of <0.05/FDR of <0.1 as the statistical cut-off. Out of the 123 genes expressed at higher levels in L&H than in HRS cells, only 27 are also up-regulated in comparison to GC B cells, and they are shown in this table. The remaining 96 genes are down-regulated in HRS cells compared with GC B cells (unpublished data).

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