Table 1.
Reagents and cell lines used in this study
Reagent or resourceSourceIdentifier
Reagents 
Antimycin A Sigma-Aldrich Catalog number A8674 
Oligomycin Calbiochem Catalog number 495455-10MGCN 
Valinomycin Sigma-Aldrich Catalog number V0627 
A/C heterodimerizer Clontech Catalog number 635057 
Q-VD-OPH SM Biochemicals Catalog number SMPH001 
Bafilomycin A1 Calbiochem Catalog number 196000 
SNIPER(CRABP)-11 This study N/A 
DMEM Sigma-Aldrich Catalog number D5796 
McCoy’s 5A Gibco Catalog number 16600-082 
FBS Biowest Catalog number S1820 
MEM nonessential amino acids solution Gibco Catalog number 11140-050 
Sodium pyruvate Gibco Catalog number 11360-070 
Penicillin–Streptomycin–Glutamine Gibco Catalog number 10378-016 
GlutaMAX supplement Gibco Catalog number 35050-061 
Hepes Gibco Catalog number 15630-080 
Opti-MEM Gibco Catalog number 31985-070 
Trypsin-EDTA (0.25%) Gibco Catalog number 25200-056 
Puromycin Sigma-Aldrich Catalog number P8833 
G418 Sigma-Aldrich Catalog number G8168-10ML 
Hygromycin B Invitrogen Catalog number 10687010 
EF1-hspCas9-H1-gRNA linearized SmartNuclease vector System Biosciences Catalog number CAS900A-1 
FuGENE6 Promega Catalog number E269A 
Lipofectamine LTX Invitrogen Catalog number 15338100 
Lipofectamine RNAiMAX Invitrogen Catalog number 13778150 
Polybrene Sigma-Aldrich Catalog number H9268 
Dithiothreitol Roche Catalog number 10708984001 
CHAPS Sigma-Aldrich Catalog number C3023 
NP-40 Nacalai Tesque Catalog number 25223-75 
cOmplete, EDTA-free protease inhibitor cocktail Roche Catalog number 11873580001 
PhosSTOP, phosphatase inhibitor cocktail Roche Catalog number 04906845001 
MLN-7243 (E1 inhibitor) Active Biochem Catalog number A-1384 
BX-795 (TBK1 inhibitor) Abcam Catalog number ab142016 
NEM Wako Pure Chemical Catalog number 058-02061 
DDDDK-tagged Protein PURIFICATION GEL MBL Catalog number 3329 
DSP Thermo Fisher Scientific Catalog number 22585 
4% PFA solution Wako Pure Chemical Catalog number 163-20145 
Gelatin Sigma-Aldrich Catalog number G9391 
Triton X-100 MP Biomedicals Catalog number 807426 
Digitonin Wako Pure Chemical Catalog number 043-21371 
Tween 20 Nacalai Tesque Catalog number 35624-15 
NuPAGE 4–12% Bis-Tris gel Invitrogen Catalog number NP0323BOX 
NuPAGE MOPS SDS running buffer Invitrogen Catalog number NP0001 
NuPAGE MOPS SDS running buffer Invitrogen Catalog number NP0002 
Difco skim milk BD Biosciences Catalog number 232100 
BSA (fatty acid free) Sigma-Aldrich Catalog number A8806 
Phusion high-fidelity DNA polymerase Thermo Fisher Scientific Catalog number F-530L 
DNA ligation kit TaKaRa Catalog number 6023 
Western Lightning Plus-ECL PerkinElmer Catalog number NEL105001EA 
ECL Prime Western blotting detection reagents GE Healthcare Catalog number RPN2232 
Cell lines 
HeLa (corresponds to WT for PINK1 KO HeLa) Okatsu et al., 2015   
PINK1 KO HeLa Okatsu et al., 2015   
HeLa (corresponds to WT for FIP200, ATG5, ATG9A, Penta KO HeLa) ATCC CCL-2,2 
FIP200 KO HeLa Vargas et al., 2019   
ATG5 KO HeLa Nezich et al., 2015   
ATG9A KO HeLa Nezich et al., 2015   
Penta (OPTN/NDP52/TAX1BP1/p62/NBR1) KO HeLa Lazarou et al., 2015   
HEK293T ATCC CRL-3216 
HT1080 Itoh et al., 2012   
HCT116 Yamano et al., 2018   
TBK1−/− HCT116 This study  
Reagent or resourceSourceIdentifier
Reagents 
Antimycin A Sigma-Aldrich Catalog number A8674 
Oligomycin Calbiochem Catalog number 495455-10MGCN 
Valinomycin Sigma-Aldrich Catalog number V0627 
A/C heterodimerizer Clontech Catalog number 635057 
Q-VD-OPH SM Biochemicals Catalog number SMPH001 
Bafilomycin A1 Calbiochem Catalog number 196000 
SNIPER(CRABP)-11 This study N/A 
DMEM Sigma-Aldrich Catalog number D5796 
McCoy’s 5A Gibco Catalog number 16600-082 
FBS Biowest Catalog number S1820 
MEM nonessential amino acids solution Gibco Catalog number 11140-050 
Sodium pyruvate Gibco Catalog number 11360-070 
Penicillin–Streptomycin–Glutamine Gibco Catalog number 10378-016 
GlutaMAX supplement Gibco Catalog number 35050-061 
Hepes Gibco Catalog number 15630-080 
Opti-MEM Gibco Catalog number 31985-070 
Trypsin-EDTA (0.25%) Gibco Catalog number 25200-056 
Puromycin Sigma-Aldrich Catalog number P8833 
G418 Sigma-Aldrich Catalog number G8168-10ML 
Hygromycin B Invitrogen Catalog number 10687010 
EF1-hspCas9-H1-gRNA linearized SmartNuclease vector System Biosciences Catalog number CAS900A-1 
FuGENE6 Promega Catalog number E269A 
Lipofectamine LTX Invitrogen Catalog number 15338100 
Lipofectamine RNAiMAX Invitrogen Catalog number 13778150 
Polybrene Sigma-Aldrich Catalog number H9268 
Dithiothreitol Roche Catalog number 10708984001 
CHAPS Sigma-Aldrich Catalog number C3023 
NP-40 Nacalai Tesque Catalog number 25223-75 
cOmplete, EDTA-free protease inhibitor cocktail Roche Catalog number 11873580001 
PhosSTOP, phosphatase inhibitor cocktail Roche Catalog number 04906845001 
MLN-7243 (E1 inhibitor) Active Biochem Catalog number A-1384 
BX-795 (TBK1 inhibitor) Abcam Catalog number ab142016 
NEM Wako Pure Chemical Catalog number 058-02061 
DDDDK-tagged Protein PURIFICATION GEL MBL Catalog number 3329 
DSP Thermo Fisher Scientific Catalog number 22585 
4% PFA solution Wako Pure Chemical Catalog number 163-20145 
Gelatin Sigma-Aldrich Catalog number G9391 
Triton X-100 MP Biomedicals Catalog number 807426 
Digitonin Wako Pure Chemical Catalog number 043-21371 
Tween 20 Nacalai Tesque Catalog number 35624-15 
NuPAGE 4–12% Bis-Tris gel Invitrogen Catalog number NP0323BOX 
NuPAGE MOPS SDS running buffer Invitrogen Catalog number NP0001 
NuPAGE MOPS SDS running buffer Invitrogen Catalog number NP0002 
Difco skim milk BD Biosciences Catalog number 232100 
BSA (fatty acid free) Sigma-Aldrich Catalog number A8806 
Phusion high-fidelity DNA polymerase Thermo Fisher Scientific Catalog number F-530L 
DNA ligation kit TaKaRa Catalog number 6023 
Western Lightning Plus-ECL PerkinElmer Catalog number NEL105001EA 
ECL Prime Western blotting detection reagents GE Healthcare Catalog number RPN2232 
Cell lines 
HeLa (corresponds to WT for PINK1 KO HeLa) Okatsu et al., 2015   
PINK1 KO HeLa Okatsu et al., 2015   
HeLa (corresponds to WT for FIP200, ATG5, ATG9A, Penta KO HeLa) ATCC CCL-2,2 
FIP200 KO HeLa Vargas et al., 2019   
ATG5 KO HeLa Nezich et al., 2015   
ATG9A KO HeLa Nezich et al., 2015   
Penta (OPTN/NDP52/TAX1BP1/p62/NBR1) KO HeLa Lazarou et al., 2015   
HEK293T ATCC CRL-3216 
HT1080 Itoh et al., 2012   
HCT116 Yamano et al., 2018   
TBK1−/− HCT116 This study  

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