Table 1. OXPHOS defects associated with... | Rockefeller University Press

Table 1.

OXPHOS defects associated with the neurodegenerative proteinopathies discussed in this review

Protein	CIV^{^a} defects	CI^{^b} defects	Mito ATP synthesis defects	ΔΨ_m^{^c} defects	Mito dynamics defects	ER–mito contact alterations	Mito Ca²⁺ handling defects
APP/Aβ	+	+	+	+	+		+
α-Syn	+	+	+	+	+	+	+
SOD1	+		+	+	+	+	+

Protein	CIV^{^a} defects	CI^{^b} defects	Mito ATP synthesis defects	ΔΨ_m^{^c} defects	Mito dynamics defects	ER–mito contact alterations	Mito Ca²⁺ handling defects
APP/Aβ	+	+	+	+	+		+
α-Syn	+	+	+	+	+	+	+
SOD1	+		+	+	+	+	+

Mito dynamics refers to the processes of fusion and fission and to mitochondrial axonal transport. ER–mito contacts refers to MAMs and functional interactions between organelles. Mito Ca²⁺ handling refers to mitochondrial calcium uptake and permeability transition.

Complex IV.

Complex I.

Mitochondrial membrane potential.

[ViewLarge]