| Complex . | Protein . | Function . |
|---|---|---|
| Core PRC1 | RING1A/B | H2A monoubiquitylation and nucleosome binding |
| PCGF1−6 | Stimulation of enzymatic activity | |
| PRC1.2, 4 | CBX2,4,6−8 | H3K9/K27me3 binding |
| PHC1−3 | Oligomerization and chromatin compaction | |
| SCMH1/L2 | Histone methyl–lysine binding and RNA binding | |
| PRC1.1, 3, 5, 6 | RYBP/YAF2 | DNA binding (unspecific) and interaction with YY1 |
| PRC1.1 | BCOR/BCORL1 | Scaffold |
| KDM2B | H3K36 demethylation and DNA binding (unmethylated CpG islands) | |
| SKP1 | Ubiquitin ligase and interaction with CUL1 | |
| USP7 | Stimulation of enzymatic activity | |
| PRC1.3, 5 | DCAF7 | Scaffold |
| CK2 | Inhibition of enzymatic activity | |
| AUTS2/FBRS/FBSL | Transcription activation | |
| PRC1.6 | WDR5 | Scaffold |
| L3MBTL2 | Histone methyl–lysine binding and chromatin compaction | |
| HP1γ/CBX3 | H3K9me3 binding | |
| JARID1C | H3K4me2/3 demethylase | |
| G9a | H3K9 methyltransferase | |
| HDAC1/2 | Histone deacetylase | |
| DP-1 | DNA binding (E2F recognition site) | |
| E2F6 | DNA binding (E2F recognition site) | |
| MAX | DNA binding (E-boxes) | |
| MGA | DNA binding (E-boxes) | |
| Core PRC2 | EZH1/2 | H3K27 methyltransferase |
| SUZ12 | DNA/RNA binding | |
| EED | H3K27me3 binding | |
| RBBP4/7 | Histones binding | |
| PRC2.1 | PCL1/PHF1 | H3K36me2/3 binding, DNA binding (unspecific), and stimulation of enzymatic activity |
| PCL2/MTF2 | H3K36me2/3 binding and DNA binding (unmethylated CpG islands) | |
| PCL3/PHF19 | H3K36me2/3 binding | |
| EPOP | Inhibition of enzymatic activity and interaction with Elongin B and C | |
| PALI1/2 | Stimulation of enzymatic activity | |
| PRC2.2 | JARID2 | DNA/RNA binding, H2Aub binding, and stimulation of enzymatic activity |
| AEBP2 | DNA binding, H2Aub binding, and stimulation of enzymatic activity |
| Complex . | Protein . | Function . |
|---|---|---|
| Core PRC1 | RING1A/B | H2A monoubiquitylation and nucleosome binding |
| PCGF1−6 | Stimulation of enzymatic activity | |
| PRC1.2, 4 | CBX2,4,6−8 | H3K9/K27me3 binding |
| PHC1−3 | Oligomerization and chromatin compaction | |
| SCMH1/L2 | Histone methyl–lysine binding and RNA binding | |
| PRC1.1, 3, 5, 6 | RYBP/YAF2 | DNA binding (unspecific) and interaction with YY1 |
| PRC1.1 | BCOR/BCORL1 | Scaffold |
| KDM2B | H3K36 demethylation and DNA binding (unmethylated CpG islands) | |
| SKP1 | Ubiquitin ligase and interaction with CUL1 | |
| USP7 | Stimulation of enzymatic activity | |
| PRC1.3, 5 | DCAF7 | Scaffold |
| CK2 | Inhibition of enzymatic activity | |
| AUTS2/FBRS/FBSL | Transcription activation | |
| PRC1.6 | WDR5 | Scaffold |
| L3MBTL2 | Histone methyl–lysine binding and chromatin compaction | |
| HP1γ/CBX3 | H3K9me3 binding | |
| JARID1C | H3K4me2/3 demethylase | |
| G9a | H3K9 methyltransferase | |
| HDAC1/2 | Histone deacetylase | |
| DP-1 | DNA binding (E2F recognition site) | |
| E2F6 | DNA binding (E2F recognition site) | |
| MAX | DNA binding (E-boxes) | |
| MGA | DNA binding (E-boxes) | |
| Core PRC2 | EZH1/2 | H3K27 methyltransferase |
| SUZ12 | DNA/RNA binding | |
| EED | H3K27me3 binding | |
| RBBP4/7 | Histones binding | |
| PRC2.1 | PCL1/PHF1 | H3K36me2/3 binding, DNA binding (unspecific), and stimulation of enzymatic activity |
| PCL2/MTF2 | H3K36me2/3 binding and DNA binding (unmethylated CpG islands) | |
| PCL3/PHF19 | H3K36me2/3 binding | |
| EPOP | Inhibition of enzymatic activity and interaction with Elongin B and C | |
| PALI1/2 | Stimulation of enzymatic activity | |
| PRC2.2 | JARID2 | DNA/RNA binding, H2Aub binding, and stimulation of enzymatic activity |
| AEBP2 | DNA binding, H2Aub binding, and stimulation of enzymatic activity |