| Gene/aliases . | KD/KO . | Developmental role . | References . |
|---|---|---|---|
| Gas6/growth arrest specific 6 | KD by RNAi | Maternal cytoplasmic maturation, sperm chromatin decondensation, pronuclear formation | Kim et al., 2011, 2018 |
| Hira/histone cell cycle regulation defective homolog A | cKO using (Tg)Zp3-Cre and (Tg)Gdf9-Cre | Transcription, replication, paternal nucleosome assembly | Lin et al., 2014; Nashun et al., 2015 |
| Npm2/nucleoplasmin 2 | KO | Nuclear and nucleolar organization, chromatin remodeling | Burns et al., 2003 |
| Scc1 (Rad21)/double-strand-break repair protein rad21 homolog | cKO using (Tg)Zp3-Cre | Mitotic sister chromatid cohesion, repair of Tet3-dependent paternal DNA lesions, higher-order chromatin structure | Ladstätter and Tachibana-Konwalski, 2016; Gassler et al., 2017 |
| Zar1/zygote arrest 1 | KO | RNA processing, pronuclear fusion | Wu et al., 2003; Hu et al., 2010 |
| Ago2/argonaute 2, RISC catalytic component | cKO using (Tg)Zp3-Cre | miRNA homeostasis, post-transcriptional gene silencing of maternal factors | Kaneda et al., 2009; conflicting arrest after two-cell (Morita et al., 2007; Lykke-Andersen et al., 2008) |
| Hsf1/heat shock factor 1 | KO | Transcription, redox-homeostasis | Christians et al., 2000; Bierkamp et al., 2010 |
| Gene/aliases . | KD/KO . | Developmental role . | References . |
|---|---|---|---|
| Gas6/growth arrest specific 6 | KD by RNAi | Maternal cytoplasmic maturation, sperm chromatin decondensation, pronuclear formation | Kim et al., 2011, 2018 |
| Hira/histone cell cycle regulation defective homolog A | cKO using (Tg)Zp3-Cre and (Tg)Gdf9-Cre | Transcription, replication, paternal nucleosome assembly | Lin et al., 2014; Nashun et al., 2015 |
| Npm2/nucleoplasmin 2 | KO | Nuclear and nucleolar organization, chromatin remodeling | Burns et al., 2003 |
| Scc1 (Rad21)/double-strand-break repair protein rad21 homolog | cKO using (Tg)Zp3-Cre | Mitotic sister chromatid cohesion, repair of Tet3-dependent paternal DNA lesions, higher-order chromatin structure | Ladstätter and Tachibana-Konwalski, 2016; Gassler et al., 2017 |
| Zar1/zygote arrest 1 | KO | RNA processing, pronuclear fusion | Wu et al., 2003; Hu et al., 2010 |
| Ago2/argonaute 2, RISC catalytic component | cKO using (Tg)Zp3-Cre | miRNA homeostasis, post-transcriptional gene silencing of maternal factors | Kaneda et al., 2009; conflicting arrest after two-cell (Morita et al., 2007; Lykke-Andersen et al., 2008) |
| Hsf1/heat shock factor 1 | KO | Transcription, redox-homeostasis | Christians et al., 2000; Bierkamp et al., 2010 |
cKO, conditional KO; KD, knockdown.