| . | Human . | Mouse . |
|---|---|---|
| First cleavage division | 27 to 30 hpf (Mio and Maeda, 2008; Wong et al., 2010; Kirkegaard et al., 2012) | 16 to 20 hpf (Arav et al., 2008; Kirkegaard et al., 2012) |
| Blastocyst implantation | 6 to 8 dpf (Hertig et al., 1956) | 4 to 4.5 dpf (Finn and McLaren, 1967) |
| Totipotent embryo | Up to four-cell (Van de Velde et al., 2008) | Up to two-cell (Tarkowski, 1959; Rossant, 1976) |
| Major ZGA | Four- to eight-cell (Tesarík et al., 1987; Braude et al., 1988; Dobson et al., 2004; Vassena et al., 2011; Yan et al., 2013) | Two-cell (Flach et al., 1982; Aoki et al., 1997; Hamatani et al., 2004) |
| DNA demethylation | Before two-cell (Guo et al., 2014b) | In early one-cell (Mayer et al., 2000; Oswald et al., 2000) |
| Chromatin accessibility | Increases during cleavage stages; detectable promoter accessibility correlates with timing of ZGA (Gao et al., 2018; Li et al., 2018) | Increases during cleavage stages; detectable promoter accessibility correlates with timing of ZGA (Lu et al., 2016; Wu et al., 2016) |
| Higher-order chromatin structure | No data available | Gradual establishment during cleavage stages (Du et al., 2017; Flyamer et al., 2017; Gassler et al., 2017; Ke et al., 2017) |
| . | Human . | Mouse . |
|---|---|---|
| First cleavage division | 27 to 30 hpf (Mio and Maeda, 2008; Wong et al., 2010; Kirkegaard et al., 2012) | 16 to 20 hpf (Arav et al., 2008; Kirkegaard et al., 2012) |
| Blastocyst implantation | 6 to 8 dpf (Hertig et al., 1956) | 4 to 4.5 dpf (Finn and McLaren, 1967) |
| Totipotent embryo | Up to four-cell (Van de Velde et al., 2008) | Up to two-cell (Tarkowski, 1959; Rossant, 1976) |
| Major ZGA | Four- to eight-cell (Tesarík et al., 1987; Braude et al., 1988; Dobson et al., 2004; Vassena et al., 2011; Yan et al., 2013) | Two-cell (Flach et al., 1982; Aoki et al., 1997; Hamatani et al., 2004) |
| DNA demethylation | Before two-cell (Guo et al., 2014b) | In early one-cell (Mayer et al., 2000; Oswald et al., 2000) |
| Chromatin accessibility | Increases during cleavage stages; detectable promoter accessibility correlates with timing of ZGA (Gao et al., 2018; Li et al., 2018) | Increases during cleavage stages; detectable promoter accessibility correlates with timing of ZGA (Lu et al., 2016; Wu et al., 2016) |
| Higher-order chromatin structure | No data available | Gradual establishment during cleavage stages (Du et al., 2017; Flyamer et al., 2017; Gassler et al., 2017; Ke et al., 2017) |
dpf, days post-fertilization; hpf, hours post-fertilization.