Table 1. Effect of GDP-locked and... | Rockefeller University Press

Table 1.

Effect of GDP-locked and GTP-locked Rags on membrane association of SPG15-GFP and mTOR

	SPG15		mTOR
Rag	fed	starved	fed	starved
Control	+	+++	+++	−
RagA^GDP	nc	nc	↓^hi	nc
RagA^GTP	↓↓	↓↓	nc	↑↑↑
RagB^GDP	nc	nc	nc	nc
RagB^GTP	↓↓	↓↓	nc	↑^hi
RagC^GDP	↑↑↑	nc	↑↑	↑↑↑
RagC^GTP	nc*	nc*	nc*	nc*
RagD^GDP	nc	nc	↑	↑↑↑
RagD^GTP	nc	nc	nc	nc

	SPG15		mTOR
Rag	fed	starved	fed	starved
Control	+	+++	+++	−
RagA^GDP	nc	nc	↓^hi	nc
RagA^GTP	↓↓	↓↓	nc	↑↑↑
RagB^GDP	nc	nc	nc	nc
RagB^GTP	↓↓	↓↓	nc	↑^hi
RagC^GDP	↑↑↑	nc	↑↑	↑↑↑
RagC^GTP	nc*	nc*	nc*	nc*
RagD^GDP	nc	nc	↑	↑↑↑
RagD^GTP	nc	nc	nc	nc

+ and −, membrane association in control cells; nc, no change compared to control; ↓↑, change in membrane association; hi, only in high expressers; *, poor expression levels.

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