Table 1. Rescue of NGF... | Rockefeller University Press

Table 1.

Rescue of NGF deprivation–induced neuronal death and degeneration by tyrosine kinase inhibitors

Target kinase	Inhibitor	Subjective survival rate
Target kinase	Inhibitor	Day2	Day3	Day4
GSK3β	CT99021	++	++	+/−
	CHIR98014 isomer	++	+	+/−
	TWS119	++	+	−
BCR, Abl, Src	Ponatinib	+++	++	+
TrkA	K-252a	++	+	+
	Lestaurtinib	+++	++	++
JNK	SP-600125	++	++	+
EGFR, HER2	CI-1033	++	++	+
	Tyrphostin B44	+++	++	++
MET, VEGFR	Sunitinib malate	+++	++	++
	Foretinib	++++	++++	++++

Target kinase	Inhibitor	Subjective survival rate
Target kinase	Inhibitor	Day2	Day3	Day4
GSK3β	CT99021	++	++	+/−
	CHIR98014 isomer	++	+	+/−
	TWS119	++	+	−
BCR, Abl, Src	Ponatinib	+++	++	+
TrkA	K-252a	++	+	+
	Lestaurtinib	+++	++	++
JNK	SP-600125	++	++	+
EGFR, HER2	CI-1033	++	++	+
	Tyrphostin B44	+++	++	++
MET, VEGFR	Sunitinib malate	+++	++	++
	Foretinib	++++	++++	++++

Neonatal rat sympathetic neurons withdrawn from NGF for 6 h were cultured without NGF and with 1 µM of tyrosine kinase inhibitors for 2–4 d more. Survival and axonal integrity was subjectively estimated on each day. “++++” cultures with morphology comparable with those maintained in NGF; “−” cultures similar to NGF-withdrawn untreated cultures.

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