Table 1.
Rescue of NGF deprivation–induced neuronal death and degeneration by tyrosine kinase inhibitors
Target kinaseInhibitorSubjective survival rate
Day2Day3Day4
GSK3β CT99021 ++ ++ +/− 
 CHIR98014 isomer ++ + +/− 
 TWS119 ++ + − 
BCR, Abl, Src Ponatinib +++ ++ + 
TrkA K-252a ++ + + 
 Lestaurtinib +++ ++ ++ 
JNK SP-600125 ++ ++ + 
EGFR, HER2 CI-1033 ++ ++ + 
 Tyrphostin B44 +++ ++ ++ 
MET, VEGFR Sunitinib malate +++ ++ ++ 
 Foretinib ++++ ++++ ++++ 

Neonatal rat sympathetic neurons withdrawn from NGF for 6 h were cultured without NGF and with 1 µM of tyrosine kinase inhibitors for 2–4 d more. Survival and axonal integrity was subjectively estimated on each day. “++++” cultures with morphology comparable with those maintained in NGF; “−” cultures similar to NGF-withdrawn untreated cultures.

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