| Gene . | Protein . | Function . |
|---|---|---|
| Secreted proteins | ||
| ALB | Human serum albumin | Carrier protein |
| AFP | α-fetoprotein | Fetal carrier protein |
| TF | Transferrin | Iron binding/transport |
| PLG | Plasminogen (Plasmin) | Proteolysis/fibrinolysis |
| SERPINA1 | α-1-antitrypsin | Protease inhibitor |
| CRP | C-reactive protein | Acute-phase protein |
| Various coagulation factors (with the exception of factor VIII) | ||
| Basolateral (sinusoidal) membrane proteins | ||
| LDLR | LDLR | Uptake of LDL particles |
| Various | Na+/K+ ATPase | Sodium/potassium exchange |
| TFRC/TFR2 | TfR | Iron import into hepatocytes |
| SLC10A1 | Sodium/bile acid cotransporter (NTCP) | Sinusoidal bile acid uptake |
| SLCO1B1/3 | Organic anion-transporting peptides | Bile acid transporters |
| PIGR | Polymeric Ig receptor | IgA transcytosis |
| ASGR1/2 | Asialoglycoprotein receptors | Glycoprotein removal |
| Apical (canalicular) membrane proteins | ||
| ABCB4 | MDR3 | Biliary phospholipid secretion |
| ABCB11 | BSEP | Bile salt efflux from hepatocytes |
| ATP8B1 | Aminophospholipid flippase | Lipid asymmetry |
| ABCG5/8 | Sterolin 1 and 2 | Sterol absorption/secretion |
| SLC4A2 | Solute carrier family 4 (AE2) | Anion exchange |
| ALPL | Liver alkaline phosphatase | Alkaline phosphatase |
| ABCB1 | MDR1 | Organic cation secretion |
| ABCC2 | MRP2 | Biliary transport |
| ABCG2 | BCRP | ABC transporter |
| Gene . | Protein . | Function . |
|---|---|---|
| Secreted proteins | ||
| ALB | Human serum albumin | Carrier protein |
| AFP | α-fetoprotein | Fetal carrier protein |
| TF | Transferrin | Iron binding/transport |
| PLG | Plasminogen (Plasmin) | Proteolysis/fibrinolysis |
| SERPINA1 | α-1-antitrypsin | Protease inhibitor |
| CRP | C-reactive protein | Acute-phase protein |
| Various coagulation factors (with the exception of factor VIII) | ||
| Basolateral (sinusoidal) membrane proteins | ||
| LDLR | LDLR | Uptake of LDL particles |
| Various | Na+/K+ ATPase | Sodium/potassium exchange |
| TFRC/TFR2 | TfR | Iron import into hepatocytes |
| SLC10A1 | Sodium/bile acid cotransporter (NTCP) | Sinusoidal bile acid uptake |
| SLCO1B1/3 | Organic anion-transporting peptides | Bile acid transporters |
| PIGR | Polymeric Ig receptor | IgA transcytosis |
| ASGR1/2 | Asialoglycoprotein receptors | Glycoprotein removal |
| Apical (canalicular) membrane proteins | ||
| ABCB4 | MDR3 | Biliary phospholipid secretion |
| ABCB11 | BSEP | Bile salt efflux from hepatocytes |
| ATP8B1 | Aminophospholipid flippase | Lipid asymmetry |
| ABCG5/8 | Sterolin 1 and 2 | Sterol absorption/secretion |
| SLC4A2 | Solute carrier family 4 (AE2) | Anion exchange |
| ALPL | Liver alkaline phosphatase | Alkaline phosphatase |
| ABCB1 | MDR1 | Organic cation secretion |
| ABCC2 | MRP2 | Biliary transport |
| ABCG2 | BCRP | ABC transporter |