| Parameters . | Descriptions . | Values . |
|---|---|---|
| R (J/mol K) | Ideal gas constant | 8.31451 |
| T (K) | Absolute temperature | 300 |
| L (μm) | Cell length | 80 |
| W (μm) | Channel width | 10 |
| H (μm) | Channel height | 10 |
| μ (Pa s) | Dynamic viscosity of the cytoplasm | 0.005 |
| μactin (Pa s) | Coefficient of friction of the actin filament | 0.01 |
| ξm (Pa s/m) | Coefficient of friction between the cell membrane and the channel wall | 3.7 × 106 |
| (Pa) | Extracellular hydrostatic pressure | 0 |
| (mM) | Extracellular osmolarity | 0 |
| cb (mM) | Intracellular osmolarity at the back | 1 |
| αb/f (m/Pa s) | Water permeability of the cell membrane | 8 × 10−11 |
| αζb/f (m/Pa s) | Water permeability of the nuclear membrane | 1 × 10−12 |
| gζb/f (μm/s) | Coefficient of effective diffusion constant at the nuclear membrane | 100 |
| (μm/s) | Maximum rate of vesicle trafficking when Tm = 0 | 0.1 |
| Tmax (N/s) | Maximum membrane tension that stalls vesicle trafficking | 0.01 |
| Fon (nN) | Cut-off force for actin polymerization | 50 |
| Foff (nN) | Cut-off force for actin depolymerization | 6 |
| Kon (1/s) | Maximum rate of actin polymerization | 3 |
| Koff (1/s) | Maximum rate of actin depolymerization | 3 |
| Δ (nm) | Effective size of a G-actin | 3 |
| (Pa) | Effective contraction stress from myosin at the back | 4,500 |
| (Pa) | Effective contraction stress from myosin at the front | 1,000 |
| Parameters . | Descriptions . | Values . |
|---|---|---|
| R (J/mol K) | Ideal gas constant | 8.31451 |
| T (K) | Absolute temperature | 300 |
| L (μm) | Cell length | 80 |
| W (μm) | Channel width | 10 |
| H (μm) | Channel height | 10 |
| μ (Pa s) | Dynamic viscosity of the cytoplasm | 0.005 |
| μactin (Pa s) | Coefficient of friction of the actin filament | 0.01 |
| ξm (Pa s/m) | Coefficient of friction between the cell membrane and the channel wall | 3.7 × 106 |
| (Pa) | Extracellular hydrostatic pressure | 0 |
| (mM) | Extracellular osmolarity | 0 |
| cb (mM) | Intracellular osmolarity at the back | 1 |
| αb/f (m/Pa s) | Water permeability of the cell membrane | 8 × 10−11 |
| αζb/f (m/Pa s) | Water permeability of the nuclear membrane | 1 × 10−12 |
| gζb/f (μm/s) | Coefficient of effective diffusion constant at the nuclear membrane | 100 |
| (μm/s) | Maximum rate of vesicle trafficking when Tm = 0 | 0.1 |
| Tmax (N/s) | Maximum membrane tension that stalls vesicle trafficking | 0.01 |
| Fon (nN) | Cut-off force for actin polymerization | 50 |
| Foff (nN) | Cut-off force for actin depolymerization | 6 |
| Kon (1/s) | Maximum rate of actin polymerization | 3 |
| Koff (1/s) | Maximum rate of actin depolymerization | 3 |
| Δ (nm) | Effective size of a G-actin | 3 |
| (Pa) | Effective contraction stress from myosin at the back | 4,500 |
| (Pa) | Effective contraction stress from myosin at the front | 1,000 |