Table 1.
Examples of rodent and human tissues cultured as organoids
TissueTypeExamples
Tissue fragmentsReconstitutedStem cell derived
Central nervous system: brain, retina Human, rat Rat hiPSC, hESC Xiang et al., 2000; van Vliet et al., 2007; Hansen et al., 2010; Eiraku et al., 2011; Qian et al., 2016; Matsui et al., 2017  
Gastrointestinal: esophagus, stomach, small intestine, colon Human, mouse  Human, mouse, hPSC, mESC Ootani et al., 2009; Barker et al., 2010; Sato et al., 2011; Bartfeld et al., 2015; Noguchi et al., 2015; Li et al., 2016  
Pancreas Human, mouse  Human, mouse, hiPSC Huch et al., 2013; Marciniak et al., 2014; Broutier et al., 2016; Hohwieler et al., 2017  
Liver Human, mouse Human Human, mouse, hiPSC Messner et al., 2013; Huch et al., 2015; Takebe et al., 2015; Broutier et al., 2016  
Kidney Mouse Human, mouse hiPSC, hESC Astashkina et al., 2012; Chang and Davies, 2012; Freedman et al., 2015; Morizane et al., 2015  
Lung Human, mouse Human, mouse hiPSC, mouse Moore et al., 2005; Wu et al., 2010; Barkauskas et al., 2013; Dye et al., 2015; Hegab et al., 2015  
Muscle: skeletal, cardiac  Human, rat, mouse hiPSC Lee et al., 2008; Madden et al., 2015; Tzatzalos et al., 2016  
Skin Human Human  Stojadinovic et al., 2013; Dos Santos et al., 2015  
Cartilage Human Human hMSC Squires et al., 2003; Caron et al., 2012; Lozito et al., 2013; Bhumiratana et al., 2014  
Artery Rat Human, mouse  Belmin et al., 1995; L’Heureux et al., 1998  
Mammary gland Human, mouse Human Human Villadsen et al., 2007; Linnemann et al., 2011; Tanos et al., 2013; Nguyen-Ngoc et al., 2015  
Prostate Human Human, rat Human, mouse Nevalainen et al., 1993; Lang et al., 2001; Karthaus et al., 2014  
Ovary, endometrium Human Human  Kwong et al., 2009; Turco et al., 2017  
Thyroid Human  mESC Toda et al., 2002; Antonica et al., 2012  
TissueTypeExamples
Tissue fragmentsReconstitutedStem cell derived
Central nervous system: brain, retina Human, rat Rat hiPSC, hESC Xiang et al., 2000; van Vliet et al., 2007; Hansen et al., 2010; Eiraku et al., 2011; Qian et al., 2016; Matsui et al., 2017  
Gastrointestinal: esophagus, stomach, small intestine, colon Human, mouse  Human, mouse, hPSC, mESC Ootani et al., 2009; Barker et al., 2010; Sato et al., 2011; Bartfeld et al., 2015; Noguchi et al., 2015; Li et al., 2016  
Pancreas Human, mouse  Human, mouse, hiPSC Huch et al., 2013; Marciniak et al., 2014; Broutier et al., 2016; Hohwieler et al., 2017  
Liver Human, mouse Human Human, mouse, hiPSC Messner et al., 2013; Huch et al., 2015; Takebe et al., 2015; Broutier et al., 2016  
Kidney Mouse Human, mouse hiPSC, hESC Astashkina et al., 2012; Chang and Davies, 2012; Freedman et al., 2015; Morizane et al., 2015  
Lung Human, mouse Human, mouse hiPSC, mouse Moore et al., 2005; Wu et al., 2010; Barkauskas et al., 2013; Dye et al., 2015; Hegab et al., 2015  
Muscle: skeletal, cardiac  Human, rat, mouse hiPSC Lee et al., 2008; Madden et al., 2015; Tzatzalos et al., 2016  
Skin Human Human  Stojadinovic et al., 2013; Dos Santos et al., 2015  
Cartilage Human Human hMSC Squires et al., 2003; Caron et al., 2012; Lozito et al., 2013; Bhumiratana et al., 2014  
Artery Rat Human, mouse  Belmin et al., 1995; L’Heureux et al., 1998  
Mammary gland Human, mouse Human Human Villadsen et al., 2007; Linnemann et al., 2011; Tanos et al., 2013; Nguyen-Ngoc et al., 2015  
Prostate Human Human, rat Human, mouse Nevalainen et al., 1993; Lang et al., 2001; Karthaus et al., 2014  
Ovary, endometrium Human Human  Kwong et al., 2009; Turco et al., 2017  
Thyroid Human  mESC Toda et al., 2002; Antonica et al., 2012  

Organoid culture has now been extended to a variety of tissues, including many from adult human primary tissue or cells. h, human; m, mouse; MSC, mesenchymal stem cell.

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