| Population | Self-renewal (number of stem cells in aged tissue) | Proliferative activity | Differentiation potential | Regeneration and repair capacity |
|---|---|---|---|---|
| HSCs | Increased approximately two- to sixfold increased | Increased | Increased myeloid cell production | Decreased engraftment potential, immune response |
| HFSCs | Maintained at equivalent levels | Reduced | Maintained at equivalent levels | Deceased hair cycling and delayed wound healing |
| ISCs | Maintained at equivalent levels | Reduced | Increased secretary lineage cells | Reduced generation after UV exposure, delayed response |
| MuSCs | Decreased approximately twofold | Reduced | Increased fibrosis after injury | Decreased engraftment potential, myofiber regeneration |
| NSCs | Decreased approximately twofold | Reduced | Maintained in vitro | Not known |
| HSCs | Increased approximately two- to sixfold increased | Increased | Increased myeloid cell production | Decreased engraftment potential, immune response |
| HFSCs | Maintained at equivalent levels | Reduced | Maintained at equivalent levels | Deceased hair cycling and delayed wound healing |
| ISCs | Maintained at equivalent levels | Reduced | Increased secretary lineage cells | Reduced generation after UV exposure, delayed response |
| MuSCs | Decreased approximately twofold | Reduced | Increased fibrosis after injury | Decreased engraftment potential, myofiber regeneration |
| NSCs | Decreased approximately twofold | Reduced | Maintained in vitro | Not known |
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