Table 1. Changes in stem cell properties... | Rockefeller University Press

Table 1.

Changes in stem cell properties with age

Population	Self-renewal (number of stem cells in aged tissue)	Proliferative activity	Differentiation potential	Regeneration and repair capacity
HSCs	Increased approximately two- to sixfold increased	Increased	Increased myeloid cell production	Decreased engraftment potential, immune response
HFSCs	Maintained at equivalent levels	Reduced	Maintained at equivalent levels	Deceased hair cycling and delayed wound healing
ISCs	Maintained at equivalent levels	Reduced	Increased secretary lineage cells	Reduced generation after UV exposure, delayed response
MuSCs	Decreased approximately twofold	Reduced	Increased fibrosis after injury	Decreased engraftment potential, myofiber regeneration
NSCs	Decreased approximately twofold	Reduced	Maintained in vitro	Not known

Population	Self-renewal (number of stem cells in aged tissue)	Proliferative activity	Differentiation potential	Regeneration and repair capacity
HSCs	Increased approximately two- to sixfold increased	Increased	Increased myeloid cell production	Decreased engraftment potential, immune response
HFSCs	Maintained at equivalent levels	Reduced	Maintained at equivalent levels	Deceased hair cycling and delayed wound healing
ISCs	Maintained at equivalent levels	Reduced	Increased secretary lineage cells	Reduced generation after UV exposure, delayed response
MuSCs	Decreased approximately twofold	Reduced	Increased fibrosis after injury	Decreased engraftment potential, myofiber regeneration
NSCs	Decreased approximately twofold	Reduced	Maintained in vitro	Not known