| Population . | Self-renewal (number of stem cells in aged tissue) . | Proliferative activity . | Differentiation potential . | Regeneration and repair capacity . |
|---|---|---|---|---|
| HSCs | Increased approximately two- to sixfold increased | Increased | Increased myeloid cell production | Decreased engraftment potential, immune response |
| HFSCs | Maintained at equivalent levels | Reduced | Maintained at equivalent levels | Deceased hair cycling and delayed wound healing |
| ISCs | Maintained at equivalent levels | Reduced | Increased secretary lineage cells | Reduced generation after UV exposure, delayed response |
| MuSCs | Decreased approximately twofold | Reduced | Increased fibrosis after injury | Decreased engraftment potential, myofiber regeneration |
| NSCs | Decreased approximately twofold | Reduced | Maintained in vitro | Not known |
| Population . | Self-renewal (number of stem cells in aged tissue) . | Proliferative activity . | Differentiation potential . | Regeneration and repair capacity . |
|---|---|---|---|---|
| HSCs | Increased approximately two- to sixfold increased | Increased | Increased myeloid cell production | Decreased engraftment potential, immune response |
| HFSCs | Maintained at equivalent levels | Reduced | Maintained at equivalent levels | Deceased hair cycling and delayed wound healing |
| ISCs | Maintained at equivalent levels | Reduced | Increased secretary lineage cells | Reduced generation after UV exposure, delayed response |
| MuSCs | Decreased approximately twofold | Reduced | Increased fibrosis after injury | Decreased engraftment potential, myofiber regeneration |
| NSCs | Decreased approximately twofold | Reduced | Maintained in vitro | Not known |