Table 1.
Genomic and physical DNA length of an average HK cell, the absolute amount of Condensin subunits on mitotic chromosomes, and their linear spacing along the chromatid axis in late prometaphase, metaphase, and early anaphase
Mitotic phase/parameterGenomic lengthPhysical lengthNumber of SMC4 (I + II)Number of CAP-D2 (I)Number of CAP-H (I)Number of CAP-D3 (II)Number of CAP-H2 (II)Number of CAP-H (I) + CAP-H2 (II)
Prometaphase         
Total 2× 7.9 Gb 1,311.7 ± 245.2 µm 247,952 ± 43,519 152,558 ± 20,965 145,478 ± 27,626 73,267 ± 14,861 36,451 ± 13,604 ~181,929 
Chromatid 123.4 Mb ~10.2 µm ~1,937 ~1,192 ~1,137 ~572 ~285 ~1,421 
1 µm ~12.0 Mb 1.0 µm ~189 ~116 ~111 ~56 ~28 ~139 
1 Mb 1.0 Mb ~83.0 nm ~16 ~10 ~9 ~5 ~2 ~12 
Genomic Condensin spacing     ~63.7 kb ~103.6 kb ~108.6 kb ~215.6 kb ~433.5 kb ~86.8 kb 
Physical Condensin spacing     ~5.3 nm ~8.6 nm ~9.0 nm ~17.9 nm ~36.0 nm ~7.2 nm 
Metaphase         
Total 2× 7.9 Gb 1,162.5 ± 190.4 µm 252,652 ± 39,130 153,519 ± 22,952 140,965 ± 26,521 71,408 ± 14,999 34,543 ± 12,521 ~175,509 
Chromatid 123.4 Mb ~9.1 µm ~1,974 ~1,199 ~1,101 ~558 ~270 ~1,371 
1 µm ~13.6 Mb 1.0 µm ~217 ~132 ~121 ~61 ~30 ~151 
1 Mb 1.0 Mb ~73.6 nm ~16 ~10 ~9 ~5 ~2 ~11 
Genomic Condensin spacing     ~62.5 kb ~102.9 kb ~112.1 kb ~221.3 kb ~457.4 kb ~90.0 kb 
Physical Condensin spacing     ~4.6 nm ~7.6 nm ~8.2 nm ~16.3 nm ~33.7 nm ~6.6 nm 
Anaphase         
Total 2× 7.9 Gb 923.1 ± 120.7 µm 325,522 ± 48,878 216,857 ± 32,900 194,427 ± 37,121 71,244 ± 16,174 34,677 ± 13,294 ~229,104 
Chromatid 123.4 Mb ~7.2 µm ~2,543 ~1,694 ~1,519 ~557 ~271 ~1,790 
1 µm ~17.1 Mb 1.0 µm ~353 ~235 ~211 ~77 ~38 ~248 
1 Mb 1.0 Mb ~58.4 nm ~21 ~14 ~12 ~5 ~2 ~15 
Genomic Condensin spacing     ~48.5 kb ~72.9 kb ~81.3 kb ~221.8 kb ~455.6 kb ~69.0 kb 
Physical Condensin spacing     ~2.8 nm ~4.3 nm ~4.7 nm ~13.0 nm ~26.6 nm ~4.0 nm 
Mitotic phase/parameterGenomic lengthPhysical lengthNumber of SMC4 (I + II)Number of CAP-D2 (I)Number of CAP-H (I)Number of CAP-D3 (II)Number of CAP-H2 (II)Number of CAP-H (I) + CAP-H2 (II)
Prometaphase         
Total 2× 7.9 Gb 1,311.7 ± 245.2 µm 247,952 ± 43,519 152,558 ± 20,965 145,478 ± 27,626 73,267 ± 14,861 36,451 ± 13,604 ~181,929 
Chromatid 123.4 Mb ~10.2 µm ~1,937 ~1,192 ~1,137 ~572 ~285 ~1,421 
1 µm ~12.0 Mb 1.0 µm ~189 ~116 ~111 ~56 ~28 ~139 
1 Mb 1.0 Mb ~83.0 nm ~16 ~10 ~9 ~5 ~2 ~12 
Genomic Condensin spacing     ~63.7 kb ~103.6 kb ~108.6 kb ~215.6 kb ~433.5 kb ~86.8 kb 
Physical Condensin spacing     ~5.3 nm ~8.6 nm ~9.0 nm ~17.9 nm ~36.0 nm ~7.2 nm 
Metaphase         
Total 2× 7.9 Gb 1,162.5 ± 190.4 µm 252,652 ± 39,130 153,519 ± 22,952 140,965 ± 26,521 71,408 ± 14,999 34,543 ± 12,521 ~175,509 
Chromatid 123.4 Mb ~9.1 µm ~1,974 ~1,199 ~1,101 ~558 ~270 ~1,371 
1 µm ~13.6 Mb 1.0 µm ~217 ~132 ~121 ~61 ~30 ~151 
1 Mb 1.0 Mb ~73.6 nm ~16 ~10 ~9 ~5 ~2 ~11 
Genomic Condensin spacing     ~62.5 kb ~102.9 kb ~112.1 kb ~221.3 kb ~457.4 kb ~90.0 kb 
Physical Condensin spacing     ~4.6 nm ~7.6 nm ~8.2 nm ~16.3 nm ~33.7 nm ~6.6 nm 
Anaphase         
Total 2× 7.9 Gb 923.1 ± 120.7 µm 325,522 ± 48,878 216,857 ± 32,900 194,427 ± 37,121 71,244 ± 16,174 34,677 ± 13,294 ~229,104 
Chromatid 123.4 Mb ~7.2 µm ~2,543 ~1,694 ~1,519 ~557 ~271 ~1,790 
1 µm ~17.1 Mb 1.0 µm ~353 ~235 ~211 ~77 ~38 ~248 
1 Mb 1.0 Mb ~58.4 nm ~21 ~14 ~12 ~5 ~2 ~15 
Genomic Condensin spacing     ~48.5 kb ~72.9 kb ~81.3 kb ~221.8 kb ~455.6 kb ~69.0 kb 
Physical Condensin spacing     ~2.8 nm ~4.3 nm ~4.7 nm ~13.0 nm ~26.6 nm ~4.0 nm 

Calculations are based on the 7.9-billion-bp HK genome with on average 64 chromosomes (Landry et al., 2013), the whole-cell chromatid lengths for late prometaphase, metaphase, and early anaphase (Fig. 4 B), and the numbers of Condensin subunits bound to chromosomes as determined by FCS-calibrated imaging (Fig. 1, C and D). The genomic and physical Condensin spacing assumes an equidistant distribution of Condensins along the mitotic chromatid axis.

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