Table 1.
Functional and histological features of dystrophic mice treated with GM1
Characteristic4 wk6 mo
mdx-R.seramdx-GM1mdx-R.seramdx-GM1
Mean ± SDnMean ± SDnMean ± SDnMean ± SDn
Body weight, g 11.08 ± 2.2 30 11.61 ± 1.79 29 28.94 ± 4.46 11 29.93 ± 3.9 11 
Wire test, seconds on wire 31.83 ± 10.6 23 33.46 ± 13.27 28 18.93 ± 10.76 11 15.6 ± 11.34 11 
Creatine kinase, IU/L 25,039 ± 11,620 6 26,851 ± 8,997 6 10,745 ± 4,959 6 11,086 ± 3,789 6 
Histopathology         
Quadriceps, % necrotic area 8.04 ± 4.35 6 11.08 ± 5.39 8 3.71 ± 1.27 9 4.82 ± 2.66 9 
Diaphragm, % necrotic area NA NA NA NA 6.69 ± 2.05 6 6.15 ± 2.22 6 
NCAM, % positive fibers 5.11 ± 2.3 13 5.91 ± 3.03 12 NA NA NA NA 
devMHC, % positive fibers 5.06 ± 1.61 9 6.79 ± 2.93 10 NA NA NA NA 

NA, not applicable.

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