Table 1. Structural features of HORMA... | Rockefeller University Press

Table 1.

Structural features of HORMA domain proteins

Protein	Open state?	Closed state?	Partner binding	Dimerization with
Mad2	✓	✓	Mad1, Cdc20, Sgo2	Mad2, p31^comet
p31^comet	—	✓	Self-bound	Mad2
Rev7	—	✓	Rev3 and others^{^a}	Rev7
HORMADs	—	✓	HORMAD C termini	?
Atg13	—	✓	Atg9?	Atg101
Atg101	✓	—	N/A	Atg13

Protein	Open state?	Closed state?	Partner binding	Dimerization with
Mad2	✓	✓	Mad1, Cdc20, Sgo2	Mad2, p31^comet
p31^comet	—	✓	Self-bound	Mad2
Rev7	—	✓	Rev3 and others^a	Rev7
HORMADs	—	✓	HORMAD C termini	?
Atg13	—	✓	Atg9?	Atg101
Atg101	✓	—	N/A	Atg13

N/A, not applicable.

Human ADAM9 and ELK1 have been shown to contain motifs fitting the consensus for Rev7 binding (Hanafusa et al., 2010), but the biological relevance of these interactions is not well established.

[ViewLarge]

Sharing Unavailable