| Protein . | Open state? . | Closed state? . | Partner binding . | Dimerization with . |
|---|---|---|---|---|
| Mad2 | ✓ | ✓ | Mad1, Cdc20, Sgo2 | Mad2, p31comet |
| p31comet | — | ✓ | Self-bound | Mad2 |
| Rev7 | — | ✓ | Rev3 and othersa | Rev7 |
| HORMADs | — | ✓ | HORMAD C termini | ? |
| Atg13 | — | ✓ | Atg9? | Atg101 |
| Atg101 | ✓ | — | N/A | Atg13 |
| Protein . | Open state? . | Closed state? . | Partner binding . | Dimerization with . |
|---|---|---|---|---|
| Mad2 | ✓ | ✓ | Mad1, Cdc20, Sgo2 | Mad2, p31comet |
| p31comet | — | ✓ | Self-bound | Mad2 |
| Rev7 | — | ✓ | Rev3 and othersa | Rev7 |
| HORMADs | — | ✓ | HORMAD C termini | ? |
| Atg13 | — | ✓ | Atg9? | Atg101 |
| Atg101 | ✓ | — | N/A | Atg13 |
N/A, not applicable.
Human ADAM9 and ELK1 have been shown to contain motifs fitting the consensus for Rev7 binding (Hanafusa et al., 2010), but the biological relevance of these interactions is not well established.