| Disorder . | Protein aggregate . | Seeding . | Intercellular transmissibility . |
|---|---|---|---|
| Prion diseases (CJD, vCJD, Kuru, and FFI) | PrPSc | Yes | Yes |
| AD | Aβ, Tau | Yes | Yes |
| Tauopathies (tauopathy, progressive supranuclear palsy, Pick’s disease, and frontotemporal dementia) | Tau | Yes | Yes |
| HD | mHtt | Yes | Yes |
| Synucleinopathies (PD, DLB, MSA, and PAF) | α-Synuclein | Yes | Yes |
| ALS | TDP-43 | Yes (Polymenidou and Cleveland, 2012) | Yes (Feiler et al., 2015) |
| FUS | Yes (Polymenidou and Cleveland, 2012) | ||
| SOD | Yes (Polymenidou and Cleveland, 2012) | Yes (Pokrishevsky et al., 2016) |
| Disorder . | Protein aggregate . | Seeding . | Intercellular transmissibility . |
|---|---|---|---|
| Prion diseases (CJD, vCJD, Kuru, and FFI) | PrPSc | Yes | Yes |
| AD | Aβ, Tau | Yes | Yes |
| Tauopathies (tauopathy, progressive supranuclear palsy, Pick’s disease, and frontotemporal dementia) | Tau | Yes | Yes |
| HD | mHtt | Yes | Yes |
| Synucleinopathies (PD, DLB, MSA, and PAF) | α-Synuclein | Yes | Yes |
| ALS | TDP-43 | Yes (Polymenidou and Cleveland, 2012) | Yes (Feiler et al., 2015) |
| FUS | Yes (Polymenidou and Cleveland, 2012) | ||
| SOD | Yes (Polymenidou and Cleveland, 2012) | Yes (Pokrishevsky et al., 2016) |
Although amyotrophic lateral sclerosis is not discussed in this review, evidence suggests that proteins involved in amyotrophic lateral sclerosis are prion-like. Evidence for seeding and transmissibility of other proteins are described in detail in the text. CJD, Creutzfeldt–Jakob disease; DLB, dementia with Lewy body; FFI, fatal familial insomnia; MSA, multiple system atrophy; PAF, pure autonomic failure; SOD, superoxide dismutase; vCJD, variant Creutzfeldt–Jakob disease.