Table 1.
Microtubule dynamics measurements
StrainDynamicityPolym ratePolym durationDepolym rateDepolym durationRescue frequencyCatastrophe frequency
 subunits/s µm/min min µm/min min events/min events/min 
WT (n = 68) 62 ± 3 2.8 ± 0.2 34 ± 2 3.2 ± 0.2 26 ± 1 1.4 ± 0.2 1.3 ± 0.2 
Dyn1-3GFP (n = 22) 68 ± 4 3.0 ± 0.3 26 ± 2 3.2 ± 0.2 20 ± 1 1.5 ± 0.4 1.1 ± 0.2 
dyn1Δ (n = 47) 49 ± 2 1.8 ± 0.1 51 ± 3 2.5 ± 0.1 34 ± 1 1.1 ± 0.2 0.9 ± 0.1 
OE-DYN1 (n = 48) 52 ± 3 2.2 ± 0.2 24 ± 3 1.9 ± 0.1 30 ± 4 1.8 ± 0.6 2.4 ± 0.5 
dyn1ΔMTBD (n = 31) 56 ± 6 1.9 ± 0.1 44 ± 2 2.5 ± 0.1 32 ± 2 1.0 ± 0.1 0.7 ± 0.1 
dyn1-WA1 (n = 52) 44 ± 2 2.0 ± 0.2 42 ± 4 2.3 ± 0.2 39 ± 3 1.3 ± 0.2 1.4 ± 0.2 
dyn1-WA3 (n = 87) 40 ± 2 1.7 ± 0.1 51 ± 2 2.2 ± 0.1 41 ± 3 1.3 ± 0.2 1.0 ± 0.2 
pac1Δ (n = 60) 48 ± 2 1.5 ± 0.1 52 ± 2 2.4 ± 0.1 32 ± 1 1.1 ± 0.2 0.8 ± 0.1 
num1Δ (n = 76) 60 ± 4 1.8 ± 0.1 41 ± 2 2.3 ± 0.1 31 ± 2 1.2 ± 0.2 1.1 ± 0.2 
nip100Δ (n = 23) 54 ± 4 1.7 ± 0.1 50 ± 3 2.6 ± 0.2 41 ± 3 0.8 ± 0.1 0.6 ± 0.1 
tub2-430Δ (n = 55) 47 ± 3 1.8 ± 0.2 61 ± 5 2.5 ± 0.2 44 ± 4 0.9 ± 0.2 0.7 ± 0.1 
StrainDynamicityPolym ratePolym durationDepolym rateDepolym durationRescue frequencyCatastrophe frequency
 subunits/s µm/min min µm/min min events/min events/min 
WT (n = 68) 62 ± 3 2.8 ± 0.2 34 ± 2 3.2 ± 0.2 26 ± 1 1.4 ± 0.2 1.3 ± 0.2 
Dyn1-3GFP (n = 22) 68 ± 4 3.0 ± 0.3 26 ± 2 3.2 ± 0.2 20 ± 1 1.5 ± 0.4 1.1 ± 0.2 
dyn1Δ (n = 47) 49 ± 2 1.8 ± 0.1 51 ± 3 2.5 ± 0.1 34 ± 1 1.1 ± 0.2 0.9 ± 0.1 
OE-DYN1 (n = 48) 52 ± 3 2.2 ± 0.2 24 ± 3 1.9 ± 0.1 30 ± 4 1.8 ± 0.6 2.4 ± 0.5 
dyn1ΔMTBD (n = 31) 56 ± 6 1.9 ± 0.1 44 ± 2 2.5 ± 0.1 32 ± 2 1.0 ± 0.1 0.7 ± 0.1 
dyn1-WA1 (n = 52) 44 ± 2 2.0 ± 0.2 42 ± 4 2.3 ± 0.2 39 ± 3 1.3 ± 0.2 1.4 ± 0.2 
dyn1-WA3 (n = 87) 40 ± 2 1.7 ± 0.1 51 ± 2 2.2 ± 0.1 41 ± 3 1.3 ± 0.2 1.0 ± 0.2 
pac1Δ (n = 60) 48 ± 2 1.5 ± 0.1 52 ± 2 2.4 ± 0.1 32 ± 1 1.1 ± 0.2 0.8 ± 0.1 
num1Δ (n = 76) 60 ± 4 1.8 ± 0.1 41 ± 2 2.3 ± 0.1 31 ± 2 1.2 ± 0.2 1.1 ± 0.2 
nip100Δ (n = 23) 54 ± 4 1.7 ± 0.1 50 ± 3 2.6 ± 0.2 41 ± 3 0.8 ± 0.1 0.6 ± 0.1 
tub2-430Δ (n = 55) 47 ± 3 1.8 ± 0.2 61 ± 5 2.5 ± 0.2 44 ± 4 0.9 ± 0.2 0.7 ± 0.1 

Sample size (n) indicates the number of GFP-Tub1–labeled astral microtubules analyzed for each genotype. Values are mean ± SEM. Boldface indicates statistical significance (P < 0.05) compared with WT, determined by t test. Bold italics indicates statistical significance (P < 0.01) compared with WT. Depolym, depolymerization; Polym, polymerization.

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