Table 1. Characteristics of the three... | Rockefeller University Press

Table 1.

Characteristics of the three actin assemblies

	Waves	Rings	Trails
Location	Undifferentiated neurites, axons, and dendrites^{^a}	Mainly axons, ∼10–20% dendrites^{^b}^,^{^c}	Axons^{^d}, ?dendrites unknown
Dynamics	Move at ∼2–3 µm/min^{^a}	None observed^{^e}	Elongate at ∼1 µm/s^{^d}
Mode of actin polymerization	Treadmilling, nucleators (Arp2/3, formins) involved^{^f}	Actin/spectrin scaffold, capping proteins^{^a}	Nucleators (formins)^{^d}
Effect of actin-disrupting agents	Yes^{^a}	Yes^{^b}	Yes^{^d}
Effect of microtubule-disrupting agents	Yes^{^a}	Yes^{^e}	No^{^d}
Initiating triggers	?	?	?Actin nucleation on endosomes^{^d}
Putative function	Deliver actin to developing growth cones^{^a}^,^{^f}^,^{^g}^,^{^h}	Support axonal plasma membrane, sodium channels in axon initiation segment^{^b}	Deliver actin to axons and synapses (axonal transport)^{^d}

	Waves	Rings	Trails
Location	Undifferentiated neurites, axons, and dendrites^{^a}	Mainly axons, ∼10–20% dendrites^{^b}^,^{^c}	Axons^{^d}, ?dendrites unknown
Dynamics	Move at ∼2–3 µm/min^{^a}	None observed^{^e}	Elongate at ∼1 µm/s^{^d}
Mode of actin polymerization	Treadmilling, nucleators (Arp2/3, formins) involved^{^f}	Actin/spectrin scaffold, capping proteins^{^a}	Nucleators (formins)^{^d}
Effect of actin-disrupting agents	Yes^{^a}	Yes^{^b}	Yes^{^d}
Effect of microtubule-disrupting agents	Yes^{^a}	Yes^{^e}	No^{^d}
Initiating triggers	?	?	?Actin nucleation on endosomes^{^d}
Putative function	Deliver actin to developing growth cones^{^a}^,^{^f}^,^{^g}^,^{^h}	Support axonal plasma membrane, sodium channels in axon initiation segment^{^b}	Deliver actin to axons and synapses (axonal transport)^{^d}

?, unknown.

Ruthel and Banker (1998).

Xu et al. (2013).

D’Este et al. (2015).

Ganguly et al. (2015).

Zhong et al. (2014).

Katsuno et al. (2015).

Ruthel and Banker (1999).

Flynn et al. (2009).